PDZ1 Domain inhibitor peptide

Product Name:PDZ1 Domain inhibitor peptide

CAS No:1315378-73-4

Purity:95%

Molar Mass:819.95

Chemical Formula:C38H61N9O11

Storage:Store at -20 degrees Celsius

Sequence:YKKTEAV

Application:

PDZ1 Domain Inhibitor Peptide is a specialized synthetic peptide that targets and inhibits the PDZ1 domain, a key protein interaction site within various signaling molecules. PDZ domains are crucial for organizing protein complexes that regulate processes like signal transduction, cell polarity, and synaptic function. By specifically inhibiting the PDZ1 domain, this peptide disrupts critical protein-protein interactions, providing researchers with a tool to study the role of PDZ domains in cellular signaling pathways. It is particularly useful in research focused on diseases such as cancer, neurological disorders, and cardiovascular conditions, where PDZ domain interactions are implicated, offering potential therapeutic insights.

Current Research:

The PDZ1 Domain Inhibitor Peptide is a cyclic peptide engineered to disrupt specific protein-protein interactions involving the PDZ1 domain of postsynaptic density protein 95 (PSD-95). By incorporating a β-alanine (β-Ala) lactam side chain linker, this peptide effectively targets the PDZ1 domain, interfering with its binding capabilities.

Mechanism of Action

This inhibitor specifically disrupts the interaction between the kainate receptor subunit GluK2 (formerly GluR6) and PSD-95. It competes with the C-terminal region of GluK2 for binding to the PDZ1 domain of PSD-95, thereby modulating synaptic signaling pathways.

Applications in Research

The PDZ1 Domain Inhibitor Peptide is a valuable tool for:

Neuroscientific Studies: Investigating the role of PSD-95 in synaptic plasticity and neurotransmission.

Pathological Research: Exploring the involvement of PDZ domain interactions in neurological disorders.

Therapeutic Development: Serving as a lead compound for designing drugs targeting PDZ domain-mediated interactions.

Handling and Storage

For optimal stability, store the peptide at -20°C, protected from light and moisture. It is soluble in water, facilitating its use in various experimental protocols.

Conclusion

The PDZ1 Domain Inhibitor Peptide offers a targeted approach to modulate PDZ domain-mediated interactions, providing insights into synaptic function and potential therapeutic avenues for neurological conditions.

Reference:

Ernst, A., Appleton, B. A., Ivarsson, Y., Zhang, Y., Gfeller, D., Wiesmann, C., & Sidhu, S. S. (2014). A structural portrait of the PDZ domain family. Journal of molecular biology, 426(21), 3509-3519.