pep4c

Product Name:pep4c

Synonyms:GluR4cr

CAS No:243843-43-8

Purity:95%

Molar Mass:1146.4

Chemical Formula:C48H91N17O13S

Storage:Store at -20 degrees Celsius

Sequence:KRMKVAKSAQ

Application:

pep4c is a potent peptide specifically designed to modulate calcium signaling pathways within cells. This peptide interacts directly with key calcium channels, influencing ion flow and affecting downstream signaling processes critical for cellular function and communication. pep4c is essential for studying calcium-dependent mechanisms, such as muscle contraction, neurotransmitter release, and cellular proliferation. Its high purity and stability ensure reliable performance in experimental setups, making it an indispensable tool for researchers investigating calcium-mediated cellular processes and potential therapeutic interventions targeting these pathways.

Current Research:

pep4c (CAS: 243843-43-8) is a synthetic decapeptide with the sequence KRMKVAKSAQ. It serves as an inactive control analog for pep2m, a peptide known to inhibit the interaction between the C-terminus of the GluA2 subunit of AMPA receptors and the N-ethylmaleimide-sensitive fusion protein (NSF). This interaction is crucial for the proper trafficking and function of AMPA receptors, which are essential for fast excitatory synaptic transmission in the central nervous system. In research settings, pep4c is utilized to validate the specificity of pep2m's effects. By comparing outcomes between pep2m and pep4c treatments, researchers can discern whether observed changes are due to the specific disruption of the GluA2-NSF interaction or are nonspecific effects. This approach enhances the reliability of studies investigating synaptic plasticity and the molecular mechanisms underlying learning and memory. For laboratory use, pep4c is typically stored desiccated at -20 degrees Celsius to maintain its stability. It is soluble up to 1 mg/mL in water, facilitating its application in various experimental protocols. In summary, pep4c functions as an essential control peptide in neuroscience research, enabling scientists to accurately assess the role of the GluA2-NSF interaction in AMPA receptor regulation and synaptic transmission.

Reference:

Li, X., Burger, S., O'Connor, A. J., Ong, L., Karas, J. A., & Gras, S. L. (2016). An enzyme-responsive controlled release system based on a dual-functional peptide. Chemical Communications, 52(29), 5112-5115.