pep2-SVKI

Product Name:pep2-SVKI

Synonyms:AKOS024456692

CAS No:328944-75-8

Purity:95%

Molar Mass:1284.5

Chemical Formula:C60H93N13O18

Storage:Store at -20 degrees Celsius

Sequence:YNVYGIESVKI

Application:

pep2-SVKI is a specialized peptide known for its role in inhibiting protein-protein interactions within specific signaling pathways. This peptide mimics a key sequence involved in the regulation of cellular functions, making it an essential tool for studying the modulation of signaling networks, especially those related to kinase activity. pep2-SVKI is highly effective in disrupting specific intracellular interactions, offering insights into therapeutic targets for diseases linked to aberrant signaling. With its high purity and consistency, pep2-SVKI provides reliable results, making it ideal for research in drug development, cancer biology, and signal transduction.

Current Research:

pep2-SVKI is a synthetic decapeptide with the sequence Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Ile (YNVYGIESVKI). It corresponds to the C-terminal sequence of the GluA2 subunit of AMPA receptors and functions as an inhibitor by disrupting the interaction between GluA2 and specific PDZ domain-containing proteins, such as glutamate receptor-interacting protein (GRIP), AMPA receptor-binding protein (ABP), and protein interacting with C kinase (PICK1). By interfering with these protein-protein interactions, pep2-SVKI modulates synaptic transmission and plasticity. Notably, it has been shown to increase the amplitude of AMPA receptor-mediated currents and block long-term depression (LTD), a synaptic mechanism associated with learning and memory. In research settings, pep2-SVKI is utilized to study the regulatory mechanisms of AMPA receptor trafficking and function. Its ability to prevent the internalization of AMPA-type glutamate receptors makes it a valuable tool for investigating synaptic plasticity and the molecular underpinnings of neurological processes. For laboratory use, pep2-SVKI is typically stored desiccated at -20 degrees Celsius to maintain its stability. It is soluble up to 1 mg/mL in water, facilitating its application in various experimental protocols. In summary, pep2-SVKI serves as a potent inhibitor of GluA2 interactions with PDZ domain-containing proteins, offering researchers a means to modulate AMPA receptor function and investigate the complex processes of synaptic transmission and plasticity.

Reference:

Pittaluga, A., Feligioni, M., Longordo, F., Luccini, E., & Raiteri, M. (2006). Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology, 50(3)