Pep1-TGL

Product Name:Pep1-TGL

Synonyms:AKOS024456696

Purity:95%

Molar Mass:990.1

Chemical Formula:C41H71N11O15S

Storage:Store at -20 degrees Celsius

Sequence:SSGMPLGATGL

Application:Pep1-TGL is a specialized peptide designed to target and modulate lipid signaling pathways within cells. This peptide plays a crucial role in investigating the dynamics of lipid-protein interactions, particularly in the context of metabolic regulation and membrane-related processes. Pep1-TGL is highly effective in studying the mechanisms underlying lipid metabolism, cellular transport, and signaling cascades associated with various metabolic disorders. With its high purity and stability, Pep1-TGL ensures consistent and reliable results, making it an essential tool for researchers exploring lipidomics, metabolic diseases, and therapeutic interventions.

Current Research:

Pep1-TGL is a synthetic peptide that mirrors the C-terminal 'TGL' motif of the GluA1 subunit of AMPA receptors. This specific sequence facilitates the study of protein-protein interactions involving GluA1, particularly those mediated by PDZ domain-containing proteins.

The 'TGL' motif at the C-terminus of GluA1 is pivotal for its interaction with scaffolding proteins, which are essential for the synaptic localization and function of AMPA receptors. By employing Pep1-TGL, researchers can investigate the binding dynamics between GluA1 and its associated proteins, thereby elucidating mechanisms underlying synaptic transmission and plasticity.

Experimental applications of Pep1-TGL have provided insights into the modulation of AMPA receptor activity. For instance, studies have utilized this peptide to disrupt GluA1 interactions, observing subsequent effects on receptor trafficking and synaptic efficacy. Such investigations are crucial for understanding the molecular basis of learning and memory, as well as the pathophysiology of neurological disorders where AMPA receptor function is altered.

In summary, Pep1-TGL serves as a valuable tool in neuropharmacological research, enabling the dissection of GluA1-mediated protein interactions. Its use contributes to a deeper comprehension of synaptic mechanisms and supports the development of therapeutic strategies targeting AMPA receptor-associated pathologies.

Reference:

Cho, J. H., Zushida, K., Shumyatsky, G. P., Carlezon, W. A., Meloni, E. G., & Bolshakov, V. Y. (2012). Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. Journal of Neuroscience, 32(41), 14165-14177.