pep2-SVKE

Product Name:pep2-SVKE

Synonyms:AKOS024456693

CAS No:1315378-76-7

Purity:95%

Molar Mass:1300.4

Chemical Formula:C59H89N13O20

Storage:Store at -20 degrees Celsius

Sequence:YNVYGIESVKE

Application:

pep2-SVKE is a highly targeted peptide designed to modulate specific protein-protein interactions within cellular signaling pathways. This peptide mimics a crucial sequence involved in regulating kinase activity, making it an invaluable tool for researchers studying phosphorylation events and their impact on cellular functions. pep2-SVKE is particularly effective in disrupting interactions that drive pathological signaling in various diseases, including cancer and neurodegenerative disorders. With its high purity and stability, pep2-SVKE delivers consistent and reliable performance, providing deep insights into the mechanisms of action and potential therapeutic interventions.

Current Research:

pep2-SVKE is a synthetic decapeptide with the sequence Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Glu (YNVYGIESVKE). It serves as an inactive control analog for pep2-SVKI, a peptide that inhibits the interaction between the C-terminus of the GluA2 subunit of AMPA receptors and PDZ domain-containing proteins such as GRIP, ABP, and PICK1. These interactions are crucial for the proper trafficking and function of AMPA receptors, which play a significant role in fast excitatory synaptic transmission in the central nervous system. In research settings, pep2-SVKE is utilized to validate the specificity of pep2-SVKI's effects. By comparing outcomes between pep2-SVKI and pep2-SVKE treatments, researchers can determine whether observed changes are due to the specific disruption of GluA2-PDZ protein interactions or are nonspecific effects. This approach enhances the reliability of studies investigating synaptic plasticity and the molecular mechanisms underlying learning and memory. For laboratory use, pep2-SVKE is typically stored desiccated at -20 degrees Celsius to maintain its stability. It is soluble up to 1 mg/mL in 67% acetic acid, facilitating its application in various experimental protocols. In summary, pep2-SVKE functions as an essential control peptide in neuroscience research, enabling scientists to accurately assess the role of GluA2 interactions with PDZ domain-containing proteins in AMPA receptor regulation and synaptic transmission.

Reference:

Liu, S. J., & Cull-Candy, S. G. (2005). Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nature neuroscience, 8(6), 768-775.