PNC-27

Product Name:PNC-27

Cas No:NA

Purity:95%

Chemical Formula:C188H293N53O44S

Molar Mass:4031.7

Storage:-20 degree Celsius

Application: PNC-27 is a synthetic peptide engineered to target and destroy cancer cells selectively, without affecting healthy tissue. It incorporates the HDM-2 binding domain of the tumor suppressor protein p53, fused with a cell-penetrating leader sequence. PNC-27 binds to HDM-2 overexpressed on tumor cell membranes, forming membrane pores that lead to rapid lysis and apoptosis. It has demonstrated potent anticancer activity in models of pancreatic, breast, melanoma, and leukemia cancers. PNC-27 is a valuable research tool in oncology, offering insight into targeted, non-genotoxic peptide therapies for drug-resistant and p53-deficient tumors.

Reference:

Sookraj, K. A., Bowne, W. B., Adler, V., Sarafraz-Yazdi, E., Michl, J., & Pincus, M. R. (2010). The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide. Cancer chemotherapy and pharmacology, 66, 325-331.