Pro-Adrenomedullin (N-20), human

Product Name:Pro-Adrenomedullin (N-20), human

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Cas No:150238-87-2

Molar Mass:2460.9

Chemical Formula:C112H178N36O27

IUPAC Name:(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid

SMILES:C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)N

InChIKey:PIRWNASAJNPKHT-SHZATDIYSA-N

InChI:InChI=1S/C112H178N36O27/c1-57(2)46-77(102(168)147-85(56-150)107(173)132-70(90(118)156)35-23-43-125-110(119)120)139-92(158)61(8)130-100(166)80(49-64-53-128-68-30-15-13-28-66(64)68)142-97(163)73(34-19-22-42-115)136-105(171)82(51-86(117)151)144-104(170)81(50-65-54-129-69-31-16-14-29-67(65)69)143-96(162)72(33-18-21-41-114)135-94(160)71(32-17-20-40-113)134-95(161)75(37-25-45-127-112(123)124)137-103(169)79(48-63-26-11-10-12-27-63)141-99(165)76(38-39-87(152)153)138-108(174)84(55-149)146-93(159)62(9)131-109(175)89(59(5)6)148-106(172)83(52-88(154)155)145-101(167)78(47-58(3)4)140-98(164)74(133-91(157)60(7)116)36-24-44-126-111(121)122/h10-16,26-31,53-54,57-62,70-85,89,128-129,149-150H,17-25,32-52,55-56,113-116H2,1-9H3,(H2,117,151)(H2,118,156)(H,130,166)(H,131,175)(H,132,173)(H,133,157)(H,134,161)(H,135,160)(H,136,171)(H,137,169)(H,138,174)(H,139,158)(H,140,164)(H,141,165)(H,142,163)(H,143,162)(H,144,170)(H,145,167)(H,146,159)(H,147,168)(H,148,172)(H,152,153)(H,154,155)(H4,119,120,125)(H4,121,122,126)(H4,123,124,127)/t60-,61-,62-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,89-/m0/s1

Sequence:Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Application:Pro-Adrenomedullin (N-20), human is a bioactive peptide fragment derived from the N-terminal region of pro-adrenomedullin (PAMP), containing the first 20 amino acids. This peptide is involved in vascular homeostasis, immune regulation, and metabolic control. Research suggests that PAMP (N-20) exhibits vasodilatory, antimicrobial, and anti-inflammatory properties, making it a valuable tool in cardiovascular, immune, and endocrine studies. It is widely used in hypertension, infection-related inflammation, and endothelial function research, with potential applications in sepsis, metabolic disorders, and stress response models. Due to its physiological relevance in humans, it is a key target for therapeutic peptide development.

Current Research:

Introduction
Pro-Adrenomedullin (N-20), human, is a truncated peptide fragment derived from pro-adrenomedullin (PAMP), the precursor protein for adrenomedullin (ADM), a potent vasodilatory and immunoregulatory peptide. This N-terminal fragment (amino acids 1-20) has gained interest in research due to its role in vascular function, immune responses, and metabolic regulation. Studies suggest PAMP (N-20) plays a critical role in endothelial homeostasis, inflammatory modulation, and stress adaptation, making it a potential biomarker and therapeutic target in cardiovascular, metabolic, and immune diseases.

Cardiovascular and Vasodilatory Research
PAMP and its derivatives, including PAMP (N-20), human, play a crucial role in vascular homeostasis and blood pressure regulation. Research findings suggest:

Activation of endothelial nitric oxide synthase (eNOS), leading to NO-mediated vasodilation and blood pressure reduction.
Regulation of vascular tone, suggesting applications in hypertension and atherosclerosis models.
Endothelial function improvement, making it relevant for studies on cardiovascular disease, arterial stiffness, and ischemic conditions.
These findings position PAMP (N-20) as a potential therapeutic target in hypertension and cardiovascular disorders.

Immunomodulatory and Anti-Inflammatory Effects
PAMP (N-20) has been linked to immune response modulation, with research highlighting its:

Suppression of pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β), potentially reducing excessive immune activation.
Modulation of immune cell activity, particularly macrophages and dendritic cells, which regulate infection responses.
Protective role in sepsis and systemic inflammatory response syndrome (SIRS), where it may help prevent cytokine storm effects.
Given these effects, PAMP (N-20) is being studied in inflammatory disease models, including autoimmune conditions and sepsis research.

Metabolic and Endocrine Research
Studies on PAMP-derived peptides indicate their potential impact on metabolic and endocrine regulation. Research suggests PAMP (N-20):

Influences insulin secretion, making it a candidate for diabetes and metabolic syndrome studies.
Interacts with stress hormone pathways, suggesting links to adrenal function and energy homeostasis.
Regulates lipid metabolism, with potential implications in obesity and cardiovascular risk reduction.
These metabolic effects suggest therapeutic potential for PAMP (N-20) in obesity, diabetes, and endocrine disorders.

Potential Research and Therapeutic Applications
Due to its vasodilatory, immune-modulating, and metabolic-regulating effects, PAMP (N-20), human, is being explored for:

Cardiovascular disease research, particularly in hypertension and endothelial dysfunction models.
Sepsis and immune-related inflammatory studies, targeting infection-induced cytokine dysregulation.
Metabolic disorder models, including insulin regulation, glucose homeostasis, and lipid metabolism research.
Conclusion
Pro-Adrenomedullin (N-20), human, is a bioactive peptide fragment involved in vascular regulation, immune response, and metabolic homeostasis. Its vasodilatory, anti-inflammatory, and metabolic properties make it a valuable research tool in cardiovascular, immunology, and endocrine studies. Ongoing research continues to explore its therapeutic potential in sepsis, blood pressure regulation, and metabolic disorders, with promising applications in biomarker discovery and peptide-based drug development.