[Pro18]-beta-Amyloid (12-28)

Product Name: [Pro18]-beta-Amyloid (12-28)

Sequence One Letter Code: VHHQKLPFFAEDVGSNK

Sequence Three Letter Code: H-Val-His-His-Gln-Lys-Leu-Pro-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

Chemical Formula:C89H133N25O25

Molecular Weight: 1953,2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: [Pro18]-Beta-Amyloid (12–28) is a modified amyloid-β fragment derived from residues 12–28, a region known to bind apolipoprotein E. Substitution of phenylalanine with proline at position 18 disrupts structural features required for apoE-mediated amyloid aggregation. Because apoE is a major genetic risk factor for Alzheimer’s disease and promotes toxic amyloid species, this peptide is useful for studying amyloid–apoE interactions. [Pro18]-Beta-Amyloid (12–28) supports research on aggregation mechanisms, structure-based inhibition, amyloid toxicity modulation, peptide–protein binding, and therapeutic strategies targeting apoE-associated amyloid pathology.