Proadrenomedullin N-terminal 20 Peptide (Human, 9-20)

Product Name:Proadrenomedullin N-terminal 20 Peptide (Human, 9-20)

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Molar Mass:1619

Chemical Formula:C77H119N25O14

Sequence:Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Application:Proadrenomedullin N-terminal 20 Peptide (Human, 9-20) is a bioactive fragment derived from proadrenomedullin (PAMP), specifically comprising amino acids 9-20 of its N-terminal region. This peptide is involved in vascular homeostasis, immune modulation, and metabolic regulation. Studies suggest that PAMP (9-20) exhibits vasodilatory, antimicrobial, and anti-inflammatory properties, making it relevant in cardiovascular research, infection control, and endocrine studies. It is widely used in studies on sepsis, inflammatory responses, and metabolic disorders, with potential applications in hypertension, immune modulation, and endothelial function regulation. PAMP-derived peptides are also investigated for their role in hypotensive effects and cell signaling pathways.

Current Research:

Introduction
Proadrenomedullin N-terminal 20 Peptide (PAMP 9-20) is a truncated peptide fragment derived from proadrenomedullin (PAMP), a precursor protein of adrenomedullin (ADM), a potent vasodilatory peptide. This short sequence (amino acids 9-20) is being investigated for its role in vascular function, immune modulation, and metabolic regulation. Unlike full-length PAMP, which has widespread effects on cardiovascular, immune, and endocrine systems, this smaller fragment may retain specific bioactivity, particularly in inflammatory responses and endothelial function.

Cardiovascular and Vasodilatory Research
PAMP and its fragments, including PAMP (9-20), have been associated with hypotensive and vasodilatory effects. Research suggests that PAMP (9-20):

Regulates vascular tone by influencing endothelial nitric oxide synthase (eNOS) activation, leading to nitric oxide (NO)-mediated vasodilation.
Reduces blood pressure through interactions with adrenergic and renin-angiotensin systems.
May improve endothelial function, potentially benefiting hypertension and atherosclerosis research.
These findings support its investigation in hypertension treatment and cardiovascular disease models.

Immunomodulatory and Anti-Inflammatory Effects
PAMP-derived peptides, including PAMP (9-20), are being studied for their immune-modulating and anti-inflammatory roles. Research highlights include:

Suppression of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, suggesting potential anti-inflammatory properties.
Modulation of macrophage function, leading to possible applications in infection control and immune suppression.
Role in sepsis and systemic inflammatory response syndrome (SIRS), where PAMP-derived peptides may reduce excessive immune activation.
Given these effects, PAMP (9-20) is being explored in infection-related inflammatory conditions.

Metabolic and Endocrine Research
Studies on PAMP and its fragments suggest potential roles in metabolism and insulin regulation. Research findings indicate that PAMP (9-20):

May influence insulin secretion, making it relevant in diabetes and metabolic syndrome studies.
Interacts with stress hormone pathways, suggesting links to adrenal function and metabolic regulation.
These findings position PAMP (9-20) as a candidate for metabolic disorder research.

Potential Research and Therapeutic Applications
Due to its vasodilatory, anti-inflammatory, and immune-modulating properties, PAMP (9-20) is being explored for:

Cardiovascular disease research, particularly in hypertension and endothelial dysfunction.
Sepsis and infection-related inflammatory response studies.
Metabolic disorder models, including diabetes and insulin regulation.
Conclusion
Proadrenomedullin N-terminal 20 Peptide (Human, 9-20) is a bioactive peptide fragment involved in vascular regulation, immune modulation, and metabolic control. Its vasodilatory, anti-inflammatory, and potential metabolic effects make it a valuable tool in cardiovascular, immunology, and endocrine research. Ongoing studies continue to explore its therapeutic potential in blood pressure regulation, infection response, and metabolic disorders.