Protease-Activated Receptor-1, PAR-1 Antagonist 2, amide

Product Name: Protease-Activated Receptor-1, PAR-1 Antagonist 2, amide

Sequence One Letter Code: S-F(para-Fluoro)-Aad-LRNP-NH2

Sequence Three Letter Code: Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2

Molecular Weight: 893

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: PAR-1 Antagonist 2 is a synthetic peptide that selectively inhibits protease-activated receptor-1, the primary thrombin receptor involved in platelet activation and vascular signaling. This antagonist inhibits SFLLRNP-induced platelet aggregation, demonstrating functional blockade of PAR-1-mediated signaling. PAR-1 antagonists are valuable tools for studying thrombin-driven cellular responses and receptor-mediated mechanisms in thrombosis, inflammation, and cardiovascular disease. PAR-1 Antagonist 2 is commonly used in pharmacological and mechanistic studies of thrombin receptor inhibition, platelet function, vascular inflammation, coagulation signaling, and therapeutic strategies targeting PAR-1-dependent disease pathways.