Protease-Activated Receptor-2, PAR-2 Agonist 2, amide

Product Name: Protease-Activated Receptor-2, PAR-2 Agonist 2, amide

Sequence One Letter Code: SLIGKV-NH2

Sequence Three Letter Code: H-Ser-Leu-Ile-Gly-Lys-Val-NH2

Cas No: 190383-13-2

Chemical Formula:C28H54N8O7

Molecular Weight: 614.8

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N

IUPAC: (2S)-6-amino-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]hexanamide

INCHIKEY: HOWDUIVVWDUEED-WAUHAFJUSA-N

INCHI:

InChI=1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: PAR-2 Activating Peptide is a synthetic peptide corresponding to the tethered ligand sequence exposed after proteolytic cleavage of protease-activated receptor-2. PAR-2 is a G protein–coupled receptor involved in inflammation, pain signaling, vascular regulation, gastrointestinal function, and immune responses. Activation of PAR-2 triggers intracellular calcium mobilization and inflammatory mediator release. This peptide is widely used as a selective pharmacological tool for studying PAR-2 receptor signaling, protease-driven inflammatory pathways, receptor activation mechanisms, and therapeutic strategies targeting PAR-mediated disorders in gastrointestinal, respiratory, immune, and vascular systems.