[Succinyl-Asp6, NMePhe8]-Substance P (6-11), Senktide

Product Name: [Succinyl-Asp6, NMePhe8]-Substance P (6-11), Senktide

Sequence One Letter Code: Suc-DF-(NMeF)-GLM-NH2

Sequence Three Letter Code: Suc-Asp-Phe-NMePhe-Gly-Leu-Met-NH2

Cas No: 106128-89-6

Chemical Formula:C40H55N7O11S

Molecular Weight: 842

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O

IUPAC: (3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(3-carboxypropanoylamino)-4-oxobutanoic acid

INCHIKEY: HMHYXLVEFVGOPM-QKUYTOGTSA-N

INCHI:

InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1

Source / Species: guinea pig

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Senktide is a synthetic tachykinin analog and highly selective agonist of the neurokinin-3 receptor. Derived from the Substance P (6–11) fragment, Senktide is widely used to investigate NK3 receptor-mediated neurotransmission, smooth muscle responses, and tachykinin signaling pathways. It has been shown to induce bronchoconstriction in guinea pig lung models, supporting its use in respiratory physiology and neurogenic inflammation research. Senktide is a valuable pharmacological probe for studying airway reactivity, neuropeptide receptor signaling, NK3 receptor function, smooth muscle contraction, and therapeutic development targeting tachykinin pathways.