Product Name:Thymalin
Cas No:63958-90-7
Purity:95%
Chemical Formula:C33H54N12O15
Molar Mass:858.9
Synonyms:Nonathymulin; Thymulin; 63958-90-7; Nonathymulin [INN]; nonathymuline; nonatimulina
IUPAC Name:(2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
SMILES:C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H]1CCC(=O)N1
InChIKey:LIFNDDBLJFPEAN-BPSSIEEOSA-N
InChI:InChI=1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1
Storage:-20 degree Celsius
Sequence:XAKSQGGSN
Application:Thymalin is a thymic peptide complex developed to restore and balance immune function, particularly in the context of aging, chronic disease, and immunodeficiency. It modulates the expression of genes involved in T-cell maturation, cytokine regulation, and antioxidant defense, promoting immune resilience and homeostasis. Thymalin enhances hematopoiesis, supports tissue regeneration, and shows anti-inflammatory and anti-fibrotic activity. It has been studied in models of immunosenescence, post-infection recovery, and degenerative disorders, where it improves immune competence and biological age markers. Thymalin is widely used in gerontology, immunology, and peptide-based regenerative medicine research.
Current Research:
Introduction: What Is Thymalin? Thymalin is a complex thymic peptide preparation derived from calf thymus extracts, originally developed in the 1970s by Russian scientists for immune restoration and aging control. It is composed of short peptides (2–5 amino acids) that influence the differentiation and maturation of immune cells, particularly T-lymphocytes. Thymalin is one of the most researched thymic peptides and is considered a foundational tool in peptide-based bioregulation, with a well-documented history of clinical and preclinical application. Mechanism of Action: Epigenetic and Immune Regulation Thymalin acts through epigenetic regulation by: Binding to specific DNA regions in immune cells Modulating the expression of genes related to: Thymocyte differentiation Cytokine production Free radical scavenging Cellular longevity and apoptosis inhibition It restores proper function of T-cell lineages, increases immune surveillance, and helps maintain balance between pro- and anti-inflammatory pathways. Thymalin also supports the formation of new blood cells by stimulating bone marrow hematopoiesis. Applications in Aging and Gerontology One of the most profound areas of Thymalin research is its role in slowing biological aging. In long-term human studies, Thymalin has been associated with: Increased thymic activity and T-cell output Reduced levels of chronic inflammation markers (e.g., IL-6, CRP) Normalization of immune system age in elderly individuals Decrease in biological age markers (e.g., epigenetic clocks, immunological profiling) Thymalin has been proposed as part of peptide geroprotective protocols, offering a non-hormonal, immune-focused tool to delay age-associated degenerative changes. Immunodeficiency and Recovery Support Thymalin has been shown to improve immune function in a wide range of acquired or secondary immunodeficiencies, such as: Post-viral immune suppression Radiation or chemotherapy-induced leukopenia Chronic infectious diseases Post-traumatic and post-surgical immune recovery In these contexts, Thymalin enhances T-cell counts, promotes NK cell activity, and restores cytokine balance, improving outcomes and shortening recovery times without immunosuppressive effects. Autoimmune Regulation and Inflammation Control Thymalin helps regulate autoimmune responses by: Supporting the maturation of regulatory T cells Reducing activity of autoreactive T-lymphocytes Lowering tissue-destructive inflammatory mediators It has been investigated in models of rheumatoid arthritis, psoriasis, and autoimmune thyroiditis, where it reduced autoimmune flare-ups and preserved tissue integrity. Its ability to rebalance immune tone makes it suitable for research into immune dysfunctions driven by chronic inflammation or autoimmunity. Hematopoietic and Regenerative Properties Thymalin supports hematopoiesis, especially in stressed bone marrow environments. Studies show: Accelerated recovery of white blood cell counts Improved platelet and erythrocyte regeneration Enhancement of hematopoietic stem cell activity It also promotes repair of damaged tissues by increasing fibroblast viability, reducing fibrosis, and stimulating angiogenesis. This makes it valuable in studies on wound healing, fibrotic disorders, and organ recovery post-injury. Conclusion Thymalin is a multifunctional peptide complex with broad immunoregulatory, hematopoietic, and regenerative effects. Its ability to restore thymic function, support immune balance, and slow biological aging makes it a cornerstone in peptide-based immunotherapy and geroprotection. With over four decades of research and clinical use, Thymalin remains a powerful tool in advancing precision immunology, anti-aging interventions, and recovery from immunosuppressive conditions.
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