Product Name: Tripeptide-41 (Lipoxin)
Cas No: 1093241-16-7
Purity: 95%
Storage: Keep in dark and cool dry place -5~8 degree Celsius
Sequence: H-Phe-Trp-Tyr-OH
Molar Mass: 514.6
Chemical Formula: C29H30N4O5
Synonyms: Phe-Trp-Tyr
IUPAC Name: (2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O)N
InChIKey: APECKGGXAXNFLL-RNXOBYDBSA-N
InChI: InChI=1S/C29H30N4O5/c30-23(14-18-6-2-1-3-7-18)27(35)32-25(16-20-17-31-24-9-5-4-8-22(20)24)28(36)33-26(29(37)38)15-19-10-12-21(34)13-11-19/h1-13,17,23,25-26,31,34H,14-16,30H2,(H,32,35)(H,33,36)(H,37,38)/t23-,25-,26-/m0/s1
Application:
Tripeptide-41 (Lipoxin) is a bioactive peptide designed to support skin-refining and contour-enhancing cosmetic applications. Known for its ability to help modulate the appearance of localized skin firmness and visibly smooth uneven texture, this peptide is often used in research targeting improved skin tone and a more sculpted look. Tripeptide-41 supports studies on reducing the look of puffiness, enhancing surface tightness, and promoting a refreshed, revitalized complexion. Its strong formulation compatibility makes it ideal for serums, slimming creams, and targeted treatments intended to deliver a more refined and resilient skin appearance.
Current Research:
Tripeptide-41 (often marketed as Lipoxin, CG-Lipoxyn or “slimming peptide”) is a synthetic tripeptide designed for localized fat reduction, anti-cellulite care, and skin firming. It’s increasingly used in body-contouring cosmetics aimed at the abdomen, thighs, hips, and arms.
Chemically, Tripeptide-41 is a short peptide with the sequence Phe–Trp–Tyr (FWY). This simple aromatic tripeptide has been engineered for high bioactivity with minimal molecular size, which helps diffusion into superficial skin layers and interaction with adipocytes (fat cells) in the subcutaneous tissue.
In the cosmetic industry it is classified as a lipolytic cosmetic peptide: an active that helps stimulate fat breakdown and improve the appearance of areas with stubborn fat deposits and cellulite. Suppliers typically describe it as a skin-conditioning and fat-reducing ingredient suitable for topical use.
Current data and technical literature describe several key actions of Tripeptide-41 that are relevant to body-contouring cosmetics:
Stimulates lipolysis – Tripeptide-41 promotes the breakdown of stored triglycerides in adipocytes into free fatty acids and glycerol, a process known as lipolysis.
Inhibits lipogenesis – It has been reported to reduce fat accumulation by down-regulating pathways associated with new lipid storage in fat cells.
Reduces adipocyte proliferation – Some in vitro data suggest it can help limit the formation of new fat cells and suppress their division, supporting long-term maintenance of results in cosmetic use.
Modulates NF-κB signaling – Tripeptide-41 has been associated with activation of NF-κB–related pathways in adipose tissue models, which appears to be linked to its ability to promote lipolysis and remodeling of adipose tissue.
From a visual result perspective, these mechanisms translate into a cosmetic claim profile aimed at smoother, firmer-looking skin and reduced appearance of localized bulges.
Supplier technical documents and secondary reviews report small-scale cosmetic studies where topical emulsions containing Tripeptide-41 were applied to areas such as the abdomen, flanks, and thighs:
Eight-week use of a body cream with Tripeptide-41 has been associated with reductions in circumference of treated areas and an improvement in the visible appearance of cellulite and skin surface irregularities.
Panelists often report better skin turgor and firmness, reflecting both underlying adipose changes and improved tissue tone.
These data are usually limited in sample size and are framed as cosmetic performance rather than therapeutic outcomes, but they support the ingredient’s positioning as a targeted slimming peptide.
In modern formulas, Tripeptide-41 is used in:
Anti-cellulite creams and gels – to help smooth the “orange-peel” look and refine body contours.
Firming body lotions – for arms, thighs, buttocks and abdomen, often combined with caffeine, L-carnitine, or other lipolytic botanicals.
Post-weight-management or “shape-up” products – to help improve the look of areas where skin appears slack or uneven.
Key cosmetic benefits highlighted:
Smoother, more uniform skin surface
Improved skin elasticity and turgor in body-care applications
A more refined and sculpted appearance of localized fat-prone zones
According to ingredient guides and supplier recommendations:
Tripeptide-41 is typically used at around 0.5–5% as active in finished body-care products, sometimes higher in professional formulations.
It is supplied as a white to off-white powder that is water-soluble and stable when stored cool and dry.
It can be incorporated into emulsions, gels, serums, and concentrated body boosters, usually in the cool-down phase to protect peptide integrity.
Because it is a small peptide, it pairs well with delivery systems such as liposomes or nanoemulsions that can improve distribution within the upper skin layers.
You can position Tripeptide-41 (Lipoxin / CG-Lipoxyn) in your cosmetic line as:
A slimming and anti-cellulite peptide that targets localized fat appearance.
A body-contouring active that supports lipolysis, reduces new fat accumulation, and helps refine silhouette.
A firming and skin-conditioning peptide that improves skin turgor and smoothness in body-care applications.
This makes Tripeptide-41 a strong hero ingredient for “sculpt & smooth” body creams, anti-cellulite gels, and firming serums designed to visibly improve the look and feel of areas prone to stubborn fat and texture irregularities.
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