Product Name:Vilon
Cas No:45234-02-4
Purity:95%
Chemical Formula:C11H21N3O5
Molar Mass:275.3
Synonyms:lysylglutamic acid; 45234-02-4; Lys-Glu; H-LYS-GLU-OH
IUPAC Name:(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid
SMILES:C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)N
InChIKey:UGTZHPSKYRIGRJ-YUMQZZPRSA-N
InChI:InChI=1S/C11H21N3O5/c12-6-2-1-3-7(13)10(17)14-8(11(18)19)4-5-9(15)16/h7-8H,1-6,12-13H2,(H,14,17)(H,15,16)(H,18,19)/t7-,8-/m0/s1
Storage:-20 degree Celsius
Sequence:KE
Application:Vilon is a short dipeptide (Lys-Glu) derived from thymic tissue, developed to regulate gene expression in immune and epithelial cells. It enhances T-cell differentiation, supports antioxidant defense, and helps normalize immune system balance disrupted by aging, chronic inflammation, or oxidative stress. Vilon has been studied in models of immunosenescence, autoimmune disorders, radiation injury, and neurodegenerative decline, where it supports both innate and adaptive immune responses. It is particularly valuable in gerontology, oncology, and regenerative immunology, offering a non-hormonal, epigenetic approach to restoring immune competence and cellular longevity.
Current Research:Introduction: What Is Vilon?
Vilon is a synthetic dipeptide (Lys-Glu) originally isolated from thymic extracts and developed as a cytogenetic peptide bioregulator to support immune system function and cellular longevity. It is one of the most extensively studied thymic peptides from the St. Petersburg Institute of Bioregulation and Gerontology, known for its epigenetic action on immune and epithelial cells.
Vilon belongs to a group of short peptides that selectively bind to DNA regulatory sequences, helping to normalize gene expression disrupted by aging, inflammation, or external stressors.
Mechanism of Action: DNA Interaction and Gene Regulation
Vilon operates at the epigenetic level, interacting with specific GC-rich sequences in the genome to regulate transcription. It modulates the expression of genes involved in:
T-cell development and activation
Cytokine production (e.g., IL-2, IFN-γ)
Apoptosis and cellular repair
Antioxidant defense and DNA stability
Through these mechanisms, Vilon restores immune homeostasis, supports tissue integrity, and helps regulate the proliferation and differentiation of lymphoid and epithelial cells.
Applications in Aging and Immunosenescence
One of Vilon’s primary applications is in gerontology, where aging is associated with:
Decreased thymic function
Reduced T-cell output
Chronic low-grade inflammation (“inflammaging”)
Oxidative stress and genomic instability
Vilon has been shown to:
Increase the proportion of naive and helper T-cells
Enhance immune surveillance and reduce reactive oxygen species (ROS)
Improve outcomes in aging-related immune dysfunction
Reduce markers of cellular senescence
These effects make it an important tool for research into healthy aging and biological age reversal.
Applications in Immunodeficiency and Chronic Inflammation
Vilon has been studied in conditions involving secondary immunodeficiency, such as:
Post-viral syndromes
Oncology-related immunosuppression
Chronic infection
Radiation or chemotherapy damage
In these models, Vilon promotes:
Recovery of leukocyte counts
Restoration of cytokine balance
Enhanced immune response to antigens
Faster resolution of inflammatory responses
It is particularly useful in recovery protocols for individuals with depleted immune reserves or high oxidative burden.
Anti-Tumor and DNA-Protective Effects
Research has also demonstrated Vilon’s ability to:
Suppress the growth of tumor cells in vitro
Enhance immune-mediated tumor clearance
Reduce DNA fragmentation and oxidative damage
Stabilize chromatin structure in aged or damaged cells
These findings suggest that Vilon may act as a genomic stabilizer, contributing to oncoprevention and radioprotection in experimental oncology.
Neuroprotection and Systemic Regeneration
Emerging data indicates that Vilon may influence neural tissue repair and cognitive preservation. It has shown:
Anti-inflammatory effects in brain tissues
Support for neuroimmune communication
Reduction of oxidative injury in neurons
This makes Vilon a potential candidate for research into neurodegeneration, stroke recovery, and brain aging.
Safety and Use
Vilon has an excellent safety profile, showing:
No toxicity or adverse immune reactions
Good tolerance in both short- and long-term studies
Compatibility with other bioregulatory peptides (e.g., Thymogen, Epitalon)
It is often used in cyclic regimens, typically over 10–30 days, and may be administered orally, sublingually, or parenterally in experimental protocols.
Conclusion
Vilon is a powerful, well-studied thymic peptide that modulates gene expression to restore immune competence, support tissue regeneration, and counteract cellular aging. Its broad biological activity—from immune support and DNA protection to oxidative stress reduction—makes it a cornerstone of peptide-based epigenetic therapy in fields such as immunology, aging science, oncology, and regenerative medicine.
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