390 MMP FRET Substrate XI

Product Name: 390 MMP FRET Substrate XI

Sequence One Letter Code: Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2

Sequence Three Letter Code: Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2

Chemical Formula:C51H65N13O15

Molecular Weight: 1100.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Conjugation: Conjugated

Conjugation Type: Double dyes

Code Nacres: NA.26

Application: 390 MMP FRET Substrate XI is a fluorogenic peptide substrate developed for monitoring matrix metalloproteinase activity. MMPs are zinc-dependent endopeptidases involved in extracellular matrix degradation, receptor cleavage, cytokine processing, cell migration, angiogenesis, and apoptosis. This substrate is efficiently hydrolyzed by MMP-8, MMP-9, and MMP-13, producing fluorescence at Abs/Em 325/393 nm. Hydrolysis is inhibited stoichiometrically by TIMP-1, TIMP-2, and TIMP-3, supporting specificity studies. 390 MMP FRET Substrate XI is widely used in enzymology, cancer research, inflammation studies, protease kinetics, and MMP inhibitor screening.