Ac-RYYRIK-NH2

Product Name:Ac-RYYRIK-NH2

CAS No:200959-48-4

Purity:95%

Molar Mass:939.1

Chemical Formula:C44H70N14O9

Storage:Store at -20 degrees Celsius

Sequence:RYYRIK

Target:NPY Y1 receptor antagonist

Application:

Ac-RYYRIK-NH₂ is a synthetic hexapeptide with the sequence acetylated at the N-terminus and amidated at the C-terminus. This peptide is a potent and selective antagonist of the neuropeptide Y (NPY) Y1 receptor. By specifically blocking the Y1 receptor, Ac-RYYRIK-NH₂ inhibits the effects of NPY, which include the regulation of food intake, anxiety, and cardiovascular functions. This makes Ac-RYYRIK-NH₂ a valuable tool in research exploring the roles of NPY in metabolic disorders, obesity, anxiety, and other related conditions. The peptide is used to investigate therapeutic strategies that target the NPY-Y1 receptor pathway for the treatment of these disorders.

Current Research:

Ac-RYYRIK-NH₂ is a synthetic hexapeptide with the sequence acetyl-Arg-Tyr-Tyr-Arg-Ile-Lys-amide. It is widely recognized as a potent and selective antagonist of the neuropeptide Y (NPY) Y5 receptor, a G protein-coupled receptor implicated in appetite regulation and energy homeostasis.

Mechanism of Action
Ac-RYYRIK-NH₂ competitively binds to the NPY Y5 receptor, preventing the activation of downstream signaling pathways typically induced by neuropeptide Y and related peptides. By antagonizing Y5 receptor activity, this peptide is instrumental in modulating physiological processes such as food intake and energy balance.

Physiological Relevance
Appetite Regulation:
The Y5 receptor is primarily involved in the central regulation of feeding behavior. Ac-RYYRIK-NH₂ blocks Y5-mediated signaling, reducing neuropeptide Y-induced appetite stimulation, making it a valuable tool in understanding mechanisms of obesity and metabolic disorders.

Energy Homeostasis:
Through its effects on the Y5 receptor, Ac-RYYRIK-NH₂ helps elucidate the role of neuropeptide Y in regulating energy expenditure and fat storage, contributing to research on metabolic diseases.

Stress and Behavior:
The Y5 receptor is also implicated in stress responses. By inhibiting Y5 activity, Ac-RYYRIK-NH₂ provides insights into the interplay between stress, appetite, and energy regulation.

Research Applications
Obesity and Metabolic Studies:
Ac-RYYRIK-NH₂ is employed in preclinical models to investigate therapeutic approaches for obesity by targeting the Y5 receptor's role in appetite control.

Neuroscience:
It serves as a valuable tool for studying the role of the NPY Y5 receptor in stress-related behaviors and its potential involvement in neuropsychiatric conditions.

Drug Development:
The peptide is used in high-throughput screening assays to identify novel compounds targeting the NPY Y5 receptor for therapeutic development.

Handling and Storage
Ac-RYYRIK-NH₂ is typically supplied as a lyophilized powder and should be stored at -20°C to maintain its stability. Reconstitution should be performed in sterile water or a buffer solution suitable for the intended experimental conditions.

Conclusion
Ac-RYYRIK-NH₂ is a crucial research tool for investigating the physiological and pathological roles of the neuropeptide Y Y5 receptor. Its specificity and potency enable detailed studies of appetite regulation, energy balance, and stress-related behaviors, contributing to the development of potential therapeutic interventions for metabolic and neuropsychiatric disorders.

Reference:

Mason, S. L., Ho, M., Nicholson, J., & McKnight, A. T. (2001). In vitro characterization of Ac-RYYRWK-NH2, Ac-RYYRIK-NH2 and [Phe1CΨ (CH2-NH) Gly2] nociceptin (1-13) NH2 at rat native and recombinant ORL1 receptors. Neuropeptides, 35(5-6), 244-256.