H-ALA-ASN-PRO-ASP-CYS-LYS-THR-ILE-LEU-LYS-ALA-LEU-GLY-PRO-ALA-ALA-THR-OH

Product Name:H-ALA-ASN-PRO-ASP-CYS-LYS-THR-ILE-LEU-LYS-ALA-LEU-GLY-PRO-ALA-ALA-THR-OH

CAS No:141281-67-6

Purity:95%

Molar Mass:1683.97

Chemical Formula:C73H126N20O23S

Storage:Room temperature

Sequence:ANPDCKTILKALGPAAT

Application:

H-ALA-ASN-PRO-ASP-CYS-LYS-THR-ILE-LEU-LYS-ALA-LEU-GLY-PRO-ALA-ALA-THR-OH is a synthetic peptide sequence commonly used in research to study protein-protein interactions, enzymatic activity, and structural biology. This peptide consists of 17 amino acids, including key residues such as cysteine (CYS), which can form disulfide bonds, and threonine (THR), which may undergo phosphorylation. The sequence's composition and structure make it suitable for exploring the functional domains of proteins, the effects of post-translational modifications, and the stability of protein folding. The free hydroxyl group (-OH) at the C-terminus ensures that the peptide retains its functional integrity in various biochemical assays, making it ideal for experimental studies in molecular biology and biochemistry.

Current Research:

The peptide sequence H-Ala-Asn-Pro-Asp-Cys-Lys-Thr-Ile-Leu-Lys-Ala-Leu-Gly-Pro-Ala-Ala-Thr-OH, corresponding to residues 194-210 of the HIV-1 Gag protein p24, is instrumental in HIV research. This segment plays a crucial role in the assembly and maturation of the viral capsid, making it a focal point for studies on viral replication and potential therapeutic interventions.
The p24 protein is a core component of the HIV-1 capsid, essential for maintaining the structural integrity of the virus. The 194-210 region contributes to the protein's ability to oligomerize, a process vital for proper capsid formation. Disruptions in this region can impair viral assembly, rendering the virus non-infectious.
Researchers utilize synthetic peptides mimicking this sequence to investigate the structural and functional aspects of p24. These studies enhance our understanding of HIV-1 assembly mechanisms and aid in the development of antiviral strategies targeting capsid formation.
Additionally, the 194-210 peptide is employed in immunological assays to evaluate immune responses against HIV-1. Its inclusion in vaccine formulations is being explored to elicit targeted immune reactions, contributing to vaccine development efforts.
In summary, the H-Ala-Asn-Pro-Asp-Cys-Lys-Thr-Ile-Leu-Lys-Ala-Leu-Gly-Pro-Ala-Ala-Thr-OH peptide is a valuable tool in HIV research, providing insights into viral assembly and informing therapeutic and vaccine development.

Reference:

Birnbaum, S., & Mosbach, K. (1992). Peptide screening. Current Opinion in Biotechnology, 3(1), 49-54.