Ac-RYYRWK-NH2

Product Name:Ac-RYYRWK-NH2

CAS No:200959-47-3

Purity:95%

Molar Mass:1012.2

Chemical Formula:C49H69N15O9

Storage:Store at -20 degrees Celsius

Sequence:RYYRWK

Target:NPY Y1 receptor antagonist

Application:

Ac-RYYRWK-NH2 is a synthetic hexapeptide, acetylated at the N-terminus and amidated at the C-terminus. This peptide is known for its high affinity and selectivity as an antagonist for the neuropeptide Y (NPY) Y1 receptor. The sequence, featuring tyrosine (Y), arginine (R), and tryptophan (W) residues, is specifically designed to block the effects of NPY on the Y1 receptor, which is involved in regulating food intake, anxiety, and cardiovascular functions. Ac-RYYRWK-NH2 is commonly used in research to study the physiological roles of the NPY-Y1 receptor pathway and to explore potential therapeutic strategies for conditions such as obesity, anxiety, and hypertension.

Current Research:

Ac-RYYRWK-NH2 is a synthetic hexapeptide with the sequence acetyl-Arg-Tyr-Tyr-Arg-Trp-Lys-amide. It is a highly specific and potent agonist of the neuropeptide Y (NPY) Y5 receptor, which is involved in regulating feeding behavior and energy homeostasis. Mechanism of Action Receptor Specificity: Ac-RYYRWK-NH2 selectively activates the Y5 receptor, a G protein-coupled receptor (GPCR) that is part of the NPY receptor family. Downstream Signaling: Upon binding to the Y5 receptor, the peptide triggers intracellular signaling cascades, including the inhibition of adenylyl cyclase, leading to decreased cyclic AMP (cAMP) levels. Physiological Roles Appetite Stimulation: The Y5 receptor is implicated in regulating appetite and energy balance. Activation by Ac-RYYRWK-NH2 promotes feeding behavior, making it a valuable tool for studying mechanisms of energy homeostasis. Energy Homeostasis: By modulating the Y5 receptor, the peptide aids in exploring how neuropeptide Y regulates energy intake and expenditure under different physiological conditions. Stress-Related Studies: The peptide is used to investigate the role of Y5 receptors in stress-induced eating behaviors. Research Applications Obesity and Metabolic Studies: Ac-RYYRWK-NH2 is utilized in research to understand how Y5 receptor activation influences appetite and metabolism, contributing to the development of anti-obesity therapies. Neuroendocrine Research: It serves as a probe to elucidate the role of neuropeptide Y and Y5 receptors in the hypothalamic regulation of energy balance. Drug Development: The peptide is a critical tool in identifying and testing potential Y5 receptor antagonists for therapeutic applications in metabolic and feeding disorders. Handling and Storage Form: Typically supplied as a lyophilized powder. Storage: Store at -20 degrees Celsius in a desiccated environment to preserve stability and bioactivity. Reconstitution: Reconstitute in sterile water or a suitable buffer for experimental use. Conclusion Ac-RYYRWK-NH2 is a highly specific and effective Y5 receptor agonist, making it indispensable in research on appetite regulation, energy balance, and neuroendocrine control. Its role in elucidating the physiological and pathological significance of Y5 receptor activation supports advances in therapeutic strategies for metabolic disorders and obesity.

Reference:

Mason, S. L., Ho, M., Nicholson, J., & McKnight, A. T. (2001). In vitro characterization of Ac-RYYRWK-NH2, Ac-RYYRIK-NH2 and [Phe1CΨ (CH2-NH) Gly2] nociceptin (1-13) NH2 at rat native and recombinant ORL1 receptors. Neuropeptides, 35(5-6), 244-256.