CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG

Product Name:CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG

CAS No:37552-33-3

Purity:95%

Molar Mass:1028.2

Chemical Formula:C44H61N13O12S2

Storage:Store at -20 degrees Celsius

Sequence:CYFQNCPR

Application:

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg is an octapeptide designed for advanced biochemical and pharmacological research. Featuring two cysteine residues, this peptide can form a disulfide bond, potentially creating a stable loop structure that enhances its interaction with specific receptors or enzymes. This sequence is commonly used in studies exploring signaling pathways, hormonal regulation, and receptor binding dynamics. Its unique structure and composition make it valuable for investigating peptide-receptor interactions, modulating immune responses, and developing peptide-based therapeutic agents. Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg is essential for research into novel treatments for a variety of diseases and conditions.

Current Research:

[Des-Gly-NH₂⁹, Arg⁸]-Vasopressin (CAS: 37552-33-3) is a synthetic analog of the neuropeptide vasopressin, characterized by the amino acid sequence Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg. This octapeptide features a disulfide bridge between the cysteine residues at positions 1 and 6, contributing to its conformational stability.

The structural modification involves the removal of the C-terminal glycinamide and the substitution of arginine at position 8, distinguishing it from native vasopressin. These alterations confer unique pharmacological properties, notably its ability to induce platelet aggregation, which has been explored for potential hemostatic applications.

In research settings, [Des-Gly-NH₂⁹, Arg⁸]-Vasopressin serves as a valuable tool for investigating vasopressin receptor interactions, signal transduction pathways, and the physiological roles of vasopressin analogs. Its specific activity profile makes it instrumental in studies related to cardiovascular function, renal physiology, and disorders involving dysregulated vasopressin activity.

For optimal stability and preservation of bioactivity, it is recommended to store this peptide at −20°C. Proper handling and storage are essential to maintain its integrity for experimental use.

In summary, [Des-Gly-NH₂⁹, Arg⁸]-Vasopressin is a synthetically engineered peptide that provides significant insights into vasopressin-related biological processes and holds potential for therapeutic exploration in hemostasis and other clinical areas.

Reference:

Lehr, C. M., Bouwstra, J. A., Kok, W., De Boer, A. G., Tukker, J. J., Verhoef, J. C., ... & Junginger, H. E. (1992). Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. Journal of pharmacy and pharmacology, 44(5), 402-407.