Allatostatin I

Product Name:Allatostatin I

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Cas No:123338-10-3

Molar Mass:1335.5

Chemical Formula:C61H94N18O16

IUPAC Name:(2S)-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2R)-1-[[2-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2R)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]propanoyl]amino]pentanediamide

SMILES:C[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC2=CC=C(C=C2)O)C(=O)NCC(=O)N[C@H](CC3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N)N

InChIKey:SDAFHXYVWUEZIJ-NDWWHVDVSA-N

InChI:InChI=1S/C61H94N18O16/c1-32(2)24-41(51(64)86)72-49(84)29-68-53(88)43(26-36-12-8-7-9-13-36)73-50(85)30-69-54(89)44(27-37-16-18-38(81)19-17-37)77-58(93)42(25-33(3)4)76-56(91)39(14-10-22-67-61(65)66)75-57(92)40(20-21-47(63)82)74-52(87)35(6)71-48(83)28-70-55(90)45(31-80)78-59(94)46-15-11-23-79(46)60(95)34(5)62/h7-9,12-13,16-19,32-35,39-46,80-81H,10-11,14-15,20-31,62H2,1-6H3,(H2,63,82)(H2,64,86)(H,68,88)(H,69,89)(H,70,90)(H,71,83)(H,72,84)(H,73,85)(H,74,87)(H,75,92)(H,76,91)(H,77,93)(H,78,94)(H4,65,66,67)/t34-,35+,39+,40+,41+,42+,43-,44-,45+,46+/m1/s1

Sequence:Ala-Pro-Ser-Gly-Ala-Gln-Arg-Leu-Tyr-Gly-Phe-Gly-Leu-NH2

Application:Allatostatin I is a neuropeptide found in insects, primarily functioning as an inhibitor of juvenile hormone (JH) synthesis in the corpora allata, regulating growth, metamorphosis, and reproduction. As a member of the allatostatin (AST) family, it also influences feeding behavior, digestive processes, and muscle contractions. By suppressing JH production, Allatostatin I plays a critical role in developmental transitions, reproductive control, and metabolic regulation. Research on Allatostatin I focuses on insect endocrinology, neuropeptide signaling, and pest control strategies, making it a valuable tool for hormonal studies, developmental biology, and sustainable insect population management.

Current Research:Allatostatin I is an important neuropeptide involved in juvenile hormone (JH) inhibition, digestive regulation, and neuropeptide signaling in insects. As part of the allatostatin family, it plays a major role in controlling growth, reproduction, and metabolism. Given its effects on hormonal pathways, research on Allatostatin I extends to pest management, metabolic regulation, and comparative endocrinology. 1. Role in Juvenile Hormone Regulation and Development Allatostatin I is secreted from neurosecretory cells in the insect brain and inhibits JH production in the corpora allata, leading to: Suppression of JH biosynthesis, reducing its influence on larval growth and reproductive processes. Acceleration of metamorphosis, shortening larval stages and promoting pupation. Reproductive inhibition, as JH is essential for ovarian maturation and egg production. These properties make Allatostatin I a valuable target for controlling insect development and reproduction, particularly in pest species. 2. Influence on Feeding Behavior and Digestive Processes Beyond JH inhibition, Allatostatin I is involved in gut function and feeding control, influencing: Gut motility, by inhibiting peristalsis and affecting food passage. Regulation of digestive enzyme activity, modifying metabolic efficiency. Feeding suppression, suggesting a role in nutrient sensing and energy homeostasis. Studies have linked Allatostatin I to insulin-like peptides (ILPs), which coordinate energy balance and metabolic adaptation. 3. Applications in Pest Control and Insecticide Development Due to its key role in growth and reproductive inhibition, Allatostatin I is being explored for eco-friendly pest management. Strategies include: Synthetic allatostatin analogs, designed to mimic its effects and reduce insect fertility. Genetic modifications affecting allatostatin signaling, leading to disrupted developmental cycles. By selectively targeting insect hormonal pathways, these methods offer sustainable alternatives to chemical pesticides. 4. Comparative Endocrinology and Evolutionary Research Allatostatins, including Allatostatin I, are structurally related to vertebrate neuropeptides such as somatostatin and galanin, leading to research on: The evolutionary origins of neuropeptide regulation. Potential similarities between insect and vertebrate metabolic control mechanisms. Conclusion Allatostatin I is a key neuropeptide that regulates juvenile hormone synthesis, feeding behavior, and gut motility in insects. Its importance in development, reproduction, and metabolism makes it a valuable target for pest control, endocrinological studies, and evolutionary biology research, offering insights into hormonal regulation and potential biotechnological applications.