Angiotensin A

Product Name:Angiotensin A

CAS No:51833-76-2

Purity:95%

Molar Mass:1002.17

Chemical Formula:C49H71N13O10

Storage:Store at -20 degrees Celsius

Sequence:ARVYIHPF

Target:RAS

Application:

Angiotensin A is a biologically active derivative of the renin-angiotensin system (RAS), similar to angiotensin II but differing by a single amino acid at the N-terminus. This peptide exerts its effects primarily through angiotensin II receptors, particularly the AT1 and AT2 receptors, but may also interact with other pathways in the cardiovascular system. Angiotensin A has been implicated in blood pressure regulation, vasoconstriction, and other cardiovascular functions. Research into this peptide explores its potential role in hypertension, heart failure, and kidney disease, providing a deeper understanding of the complexity of RAS and its implications for cardiovascular health.

Current Research:

Angiotensin A (Ang A) is a peptide hormone closely related to angiotensin II (Ang II), differing by a single amino acid substitution where the N-terminal aspartic acid is replaced by alanine. This minor alteration significantly influences its biological activity and interaction with angiotensin receptors. Formation and Structure Ang A is generated through the decarboxylation of Ang II, a process facilitated by enzymatic activity under specific physiological conditions. The substitution of aspartic acid with alanine at the N-terminus distinguishes Ang A from Ang II, potentially altering its receptor binding affinity and subsequent physiological effects. Physiological Role The precise functions of Ang A are not fully elucidated; however, it is believed to interact with the same receptors as Ang II, namely AT1 and AT2 receptors. Preliminary studies suggest that Ang A may exhibit vasoconstrictive properties similar to Ang II, contributing to blood pressure regulation and fluid balance. Additionally, Ang A might play a role in modulating aldosterone secretion, thereby influencing sodium and water homeostasis. Clinical Implications Understanding the role of Ang A in the renin-angiotensin system (RAS) could provide insights into novel therapeutic targets for cardiovascular diseases. Given its structural similarity to Ang II, Ang A may be involved in pathophysiological conditions such as hypertension, heart failure, and renal disorders. Further research is necessary to delineate its specific contributions and potential as a biomarker or therapeutic target. Research Directions Ongoing studies aim to clarify the receptor binding dynamics of Ang A and its physiological and pathological roles. Investigating its effects on vascular tone, cardiac function, and renal physiology will enhance our comprehension of its significance within the RAS. Moreover, exploring the regulatory mechanisms governing its formation and degradation could reveal new aspects of cardiovascular regulation. Conclusion Angiotensin A represents a variant of the well-characterized angiotensin II, with potential implications in cardiovascular physiology and pathology. Elucidating its functions and interactions within the RAS may open avenues for innovative therapeutic strategies in managing cardiovascular diseases.

Reference:

Santos, R. A. (2014). Angiotensin-(1–7). Hypertension, 63(6), 1138-1147.