Bim BH3, Peptide IV

Product Name: Bim BH3, Peptide IV

Sequence One Letter Code: DMRPEIWIAQELRRIGDEFNAYYARR

Sequence Three Letter Code: H-Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg-OH

Chemical Formula:C145H222N44O41S1

Molecular Weight: 3269.9

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Bim BH3 Peptide IV is a synthetic peptide derived from the BH3 domain of Bim, a pro-apoptotic member of the Bcl-2 protein family. The BH3 domain is critical for initiating intrinsic apoptosis by binding anti-apoptotic Bcl-2 family proteins and promoting mitochondrial outer membrane permeabilization. This peptide is widely used to study Bcl-2 family protein interactions, mitochondrial apoptosis mechanisms, programmed cell death, and apoptotic resistance in cancer biology. Bim BH3 Peptide IV is also valuable in drug discovery research focused on therapeutic strategies that target survival pathways and restore apoptosis in resistant cells.