Bombinakinin M

Product Name:Bombinakinin M

CAS No:509151-65-9

Purity:95%

Molar Mass:2179.55

Chemical Formula:C100H159N31O24

Storage:Store at -20 degrees Celsius

Sequence:DLPKINRKGPRPPGFSPFR

Target:bradykinin receptor agonist

Application:

Bombinakinin M is a bioactive peptide derived from the skin secretions of Bombina frogs, classified within the tachykinin family, which is known for roles in neurotransmission and smooth muscle contraction. Structurally related to substance P, Bombinakinin M influences key physiological processes, including pain modulation, inflammation, and cardiovascular regulation. It interacts with neurokinin receptors, making it a valuable research tool for studying the nervous and cardiovascular systems. Researchers use Bombinakinin M to investigate mechanisms underlying pain perception, inflammatory responses, and blood pressure control, contributing to the development of potential therapies for conditions like chronic pain, inflammation, and hypertension.

Current Research:

Bombinakinin M is a bradykinin-related peptide isolated from the skin secretions of the toad Bombina maxima. It functions as a bradykinin receptor agonist, exhibiting contractile activity in the guinea pig ileum. This activity suggests that Bombinakinin M can interact with bradykinin receptors, leading to smooth muscle contraction.
Structure
The peptide's amino acid sequence is:
Asp-Leu-Pro-Lys-Ile-Asn-Arg-Lys-Gly-Pro-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
This sequence shares homology with other bradykinin-related peptides, indicating a conserved mechanism of action through bradykinin receptor activation.
Biological Activity
In pharmacological studies, Bombinakinin M has demonstrated the ability to induce contractions in isolated guinea pig ileum preparations. This effect is mediated through the activation of bradykinin receptors, which are known to play roles in various physiological processes, including vasodilation, pain sensation, and smooth muscle contraction.
Research Applications
Due to its specific activity, Bombinakinin M serves as a valuable tool in:
Pharmacological Research: Investigating the roles of bradykinin receptors in smooth muscle physiology and their potential as therapeutic targets.
Comparative Physiology: Studying the evolution and function of bradykinin-related peptides across different species.
Handling and Storage
For laboratory use, Bombinakinin M is typically supplied as a lyophilized powder. It is recommended to rehydrate the peptide immediately before use to ensure stability and activity. Unused portions should not be refrozen to maintain integrity.
Conclusion
Bombinakinin M exemplifies the diverse array of bioactive peptides found in amphibian skin secretions. Its ability to activate bradykinin receptors and induce smooth muscle contraction makes it a significant subject for research into bradykinin-mediated physiological processes and potential therapeutic applications.

Reference:

Lee, W. H., Liu, S. B., Shen, J. H., Jin, Y., & Zhang, Y. (2005). Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide. Regulatory peptides, 127(1-3), 207-215.