Bradykinin; Angiotensin I Converting Enzyme (ACE I) Inhibitor

Bradykinin-Derived ACE I Inhibitor Peptide is a synthetic peptide derived from bradykinin and functions as an inhibitor of angiotensin I-converting enzyme. ACE I is a key regulator of the renin–angiotensin–aldosterone system and catalyzes the conversion of angiotensin I to the vasoconstrictor angiotensin II through a zinc- and chloride-dependent mechanism. By inhibiting ACE I, this peptide supports studies of blood pressure regulation, vascular tone, and peptide processing. It is widely used in cardiovascular, renal, hypertension, RAAS signaling, and ACE-dependent enzyme activity research.

Product Name: Bradykinin; Angiotensin I Converting Enzyme (ACE I) Inhibitor

Sequence One Letter Code: RPPGFSPFR

Sequence Three Letter Code: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

Chemical Formula:C50H73N15O11

Molecular Weight: 1060.3

Cas No: 58-82-2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: frog

Conjugation: Unconjugated

Code Nacres: NA.26

SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

IUPAC: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

INCHIKEY: QXZGBUJJYSLZLT-FDISYFBBSA-N

INCHI:

InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1