Calcitonin Gene Related Peptide, CGRP (beta), human

Product Name: Calcitonin Gene Related Peptide, CGRP (beta), human

Sequence One Letter Code: ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-NH2 (Disulfide bridge:2-7)

Sequence Three Letter Code: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge:2-7)

Cas No: 101462-82-2

Chemical Formula:C162H267N51O48S3

Molecular Weight: 3793.4

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)O

IUPAC: (2S)-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-4-amino-2-[[(2R)-2-[[(2S)-2-aminopropanoyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]acetyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]butanediamide

INCHIKEY: TXKXUYBRZJPFDF-GWXQVRSKSA-N

INCHI:

InChI=1S/C162H269N51O48S3/c1-74(2)53-98(186-118(227)65-178-130(231)82(16)182-139(240)99(54-75(3)4)193-135(236)94(43-34-49-175-161(170)171)188-142(243)102(58-91-62-174-73-181-91)198-158(259)127(88(22)221)212-155(256)122(79(11)12)207-151(252)111(72-263)204-159(260)125(86(20)219)209-132(233)84(18)184-156(257)124(85(19)218)210-146(247)104(60-114(167)223)197-150(251)110(71-262)203-129(230)81(15)165)140(241)194-100(55-76(5)6)141(242)202-108(69-216)148(249)190-95(44-35-50-176-162(172)173)137(238)200-106(67-214)133(234)179-63-116(225)177-64-117(226)185-96(46-52-264-23)138(239)206-121(78(9)10)154(255)191-93(42-31-33-48-164)136(237)201-109(70-217)149(250)196-103(59-113(166)222)143(244)195-101(57-90-39-28-25-29-40-90)144(245)208-123(80(13)14)160(261)213-51-36-45-112(213)152(253)211-126(87(21)220)157(258)199-105(61-115(168)224)145(246)205-120(77(7)8)153(254)180-66-119(228)187-107(68-215)147(248)189-92(41-30-32-47-163)134(235)183-83(17)131(232)192-97(128(169)229)56-89-37-26-24-27-38-89/h24-29,37-40,62,73-88,92-112,120-127,214-221,262-263H,30-36,41-61,63-72,163-165H2,1-23H3,(H2,166,222)(H2,167,223)(H2,168,224)(H2,169,229)(H,174,181)(H,177,225)(H,178,231)(H,179,234)(H,180,254)(H,182,240)(H,183,235)(H,184,257)(H,185,226)(H,186,227)(H,187,228)(H,188,243)(H,189,248)(H,190,249)(H,191,255)(H,192,232)(H,193,236)(H,194,241)(H,195,244)(H,196,250)(H,197,251)(H,198,259)(H,199,258)(H,200,238)(H,201,237)(H,202,242)(H,203,230)(H,204,260)(H,205,246)(H,206,239)(H,207,252)(H,208,245)(H,209,233)(H,210,247)(H,211,253)(H,212,256)(H4,170,171,175)(H4,172,173,176)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,120-,121-,122-,123-,124-,125-,126-,127-/m0/s1

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Human β-CGRP is a 37-amino-acid neuropeptide closely related to α-CGRP and involved in cardiovascular, nervous system, and inflammatory regulation. The peptide contains an N-terminal disulfide bond, a C-terminal phenylalanine amide important for receptor recognition, and an α-helical region between residues 8 and 18 that supports biological activity. Acting through G protein-coupled CGRP receptors, β-CGRP modulates vasodilation, nociception, and neurogenic inflammation. This peptide is widely used in neuroscience, cardiovascular research, migraine studies, vascular biology, receptor pharmacology, and investigations of CGRP-mediated signaling pathways.