CALP2

Product Name: CALP2

CAS No: 261969-04-4

Purity: 95%

Molar Mass: 1357.7

Chemical Formula: C68H104N14O13S

Storage: Store at -20 degrees Celsius

Sequence: VKFGVGFKVMVF

Target: calmodulin

Application:

CALP2 is a synthetic peptide derived from the calpain family of calcium-dependent proteases. It functions as an activator of calpain enzymes, promoting the cleavage of specific substrate proteins involved in cellular processes such as cytoskeletal remodeling, signal transduction, and apoptosis. CALP2's ability to enhance calpain activity makes it a useful tool in research focused on understanding the roles of calpain in neurodegeneration, muscle function, and cardiovascular diseases. Additionally, its potential therapeutic applications include the treatment of conditions associated with calpain dysregulation, such as Alzheimer's disease, muscular dystrophy, and ischemic injury.

Current Research:

CALP2 is a synthetic peptide that functions as a potent calmodulin (CaM) antagonist, exhibiting high-affinity binding to the EF-hand/Ca²⁺-binding sites of CaM. By inhibiting CaM-dependent processes, CALP2 disrupts key cellular signaling pathways, including the regulation of phosphodiesterase activity, leading to increased intracellular Ca²⁺ concentrations. This unique mechanism positions CALP2 as a valuable tool in exploring CaM-mediated cellular functions.

In immunological research, CALP2 is recognized for its role as an activator of macrophages, enhancing their superoxide production and modulating immune responses. This property is particularly relevant in studying inflammatory processes and immune cell behavior. Additionally, CALP2 has been implicated in neuropathic pain mechanisms, where it influences the expression of tumor necrosis factor-alpha (TNF-α) following nerve injury. This regulation of inflammatory mediators highlights its potential in therapeutic strategies for pain management.

Further research has demonstrated CALP2's involvement in cellular adhesion and degranulation processes. By targeting CaM activity, CALP2 provides insights into the modulation of immune cell adhesion and the mechanisms underlying degranulation, which are crucial for understanding immune responses and related pathologies.

CALP2 continues to serve as a significant molecular tool in studying calmodulin-regulated pathways. Its ability to modulate calcium signaling and immune functions has broad implications in cell biology, immunology, and therapeutic research. Ongoing studies aim to further elucidate its mechanisms and explore its potential in developing targeted interventions for calmodulin-related disorders.

Chen, S. X., Wang, S. K., Yao, P. W., Liao, G. J., Na, X. D., Li, Y. Y., … & Zang, Y. (2018). Early CALP 2 expression and microglial activation are potential inducers of spinal IL‐6 up‐regulation and bilateral pain following motor nerve injury. Journal of neurochemistry, 145(2), 154-169.