CSP-1, Competence-Stimulating Peptide-1

Product Name: CSP-1, Competence-Stimulating Peptide-1

Sequence One Letter Code: EMRLSKFFRDFILQRKK

Sequence Three Letter Code: H-Glu-Met-Arg-Leu-Ser-Lys-Phe-Phe-Arg-Asp-Phe-Ile-Leu-Gln-Arg-Lys-Lys-OH

Chemical Formula:C103H168N30O24S1

Molecular Weight: 2242.8

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: streptococcus

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Competence-Stimulating Peptide-1 (CSP-1) is a 17-amino-acid quorum-sensing pheromone secreted by Streptococcus pneumoniae. CSP-1 activates the ComABCDE signal transduction pathway, which regulates natural genetic competence and DNA uptake in bacterial cells. The mature pheromone is strain specific and derived from a ribosomally synthesized precursor peptide. CSP-1 from strain Rx is commonly used to study bacterial communication, quorum sensing, horizontal gene transfer, and genetic transformation. This peptide is a valuable research tool for investigating microbial signaling networks, competence regulation, Gram-positive bacterial physiology, and mechanisms controlling DNA uptake in pneumococcal systems.