Des-Arg9-Bradykin

Product Name: Des-Arg9-Bradykin

Sequence One Letter Code: RPPGFSPF

Sequence Three Letter Code: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

Cas No: 15958-92-6

Chemical Formula:C44H61N11O10

Molecular Weight: 904.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O

IUPAC: (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

INCHIKEY: VCEHWDBVPZFHAG-POFDKVPJSA-N

INCHI:

InChI=1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1

Conjugation: Unconjugated

Code Nacres: NA.27

Application: Des-Arg⁹-Bradykinin is a biologically active metabolite of bradykinin generated through carboxypeptidase-mediated removal of the C-terminal arginine residue. This peptide selectively acts as an agonist of the bradykinin B1 receptor, which is typically induced under inflammatory, pathological, and tissue injury conditions. Des-Arg⁹-Bradykinin is widely used to study kinin receptor signaling, inflammatory pathways, pain sensitization, vascular permeability, and cardiovascular responses. It serves as an important pharmacological tool for investigating B1 receptor-mediated mechanisms in inflammation, vascular biology, chronic pain models, and disease-associated kinin system activation.