[Des-octanoyl]-Ghrelin (rat)

Product Name:[Des-octanoyl]-Ghrelin (rat)

CAS No:307950-60-3

Purity:95%

Molar Mass:3188.63

Chemical Formula:C139H231N45O41

Storage:Store at -20 degrees Celsius

Sequence:GSSFLSPEHQKAQQRKESKKPPAKLQPR

Target:GHS-R1a

Application:

[Des-octanoyl]-Ghrelin (rat) is a form of ghrelin that lacks the octanoyl modification at the serine-3 position, which is essential for activating the ghrelin receptor (GHS-R1a). This des-octanoylated version does not stimulate the growth hormone secretion and appetite regulation that are typical of acylated ghrelin. However, it still plays a role in other physiological processes, such as cell proliferation, cardiovascular function, and metabolic regulation. [Des-octanoyl]-Ghrelin (rat) is widely used in research to differentiate the effects of acylated and non-acylated ghrelin, providing insights into the broader biological actions of ghrelin beyond its role in energy homeostasis.

Current Research:

[Des-octanoyl]-Ghrelin, also known as des-acyl ghrelin, is the predominant circulating form of ghrelin in rats. Unlike its acylated counterpart, ghrelin, [des-octanoyl]-ghrelin lacks the octanoyl modification at the serine-3 position, a modification essential for binding to the growth hormone secretagogue receptor (GHS-R1a). Consequently, [des-octanoyl]-ghrelin does not activate GHS-R1a and does not stimulate growth hormone release.
Despite its inability to engage GHS-R1a, [des-octanoyl]-ghrelin exhibits significant biological activity through alternative mechanisms. Studies have shown that it can decrease food intake and reduce gastroduodenal motility in conscious rats, likely by crossing the blood-brain barrier and directly activating central receptors. Additionally, [des-octanoyl]-ghrelin has been observed to counteract the metabolic effects of acylated ghrelin, such as inhibiting hepatic glucose output, indicating a role in energy homeostasis.
The distinct functions of [des-octanoyl]-ghrelin suggest that it may interact with receptors other than GHS-R1a, though these receptors have yet to be definitively identified. Ongoing research aims to elucidate the specific pathways and receptors involved in mediating the effects of [des-octanoyl]-ghrelin, which could have implications for understanding metabolic regulation and developing therapeutic strategies for related disorders.
In summary, [des-octanoyl]-ghrelin is a non-acylated form of ghrelin that, despite not activating GHS-R1a or inducing growth hormone release, plays a significant role in modulating physiological processes such as appetite, gastrointestinal motility, and glucose metabolism through mechanisms that are currently under active investigation.

Reference:

Li, L., Zhang, L. K., Pang, Y. Z., Pan, C. S., Qi, Y. F., Chen, L., ... & Zhang, J. (2006). Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Acta Pharmacologica Sinica, 27(5), 527-535.