Eledoisin-Related Peptide

Product Name:Eledoisin-Related Peptide

Synonyms:Lysyl-phenylalanyl-isoleucyl-glycyl-leucyl-methioninamide

CAS No:2990-43-4

Purity:95%

Molar Mass:706.9

Chemical Formula:C34H58N8O6S

Storage:Store at -20 degrees Celsius

Sequence:KFIGLM

Application:Eledoisin-Related Peptide

Current Research:

Eledoisin-Related Peptide: Structure and Biological Activity
Eledoisin-related peptide (ERP) is a bioactive octapeptide closely related to eledoisin, both of which belong to the tachykinin family of neuropeptides. Its sequence is Ala-Gly-His-Ser-Asp-Gly-Phe-Ile, differing slightly from eledoisin, yet maintaining the conserved structural motifs necessary for receptor binding. ERP exerts its effects by interacting primarily with neurokinin (NK) receptors, particularly NK1 and NK2, which are involved in modulating smooth muscle activity, pain perception, and inflammatory responses.
Physiological Functions
Smooth Muscle Contraction: ERP induces contractions in gastrointestinal and respiratory smooth muscles, mirroring the effects of related tachykinins. Its potent action on these tissues highlights its regulatory role in visceral motility.
Pain and Nociception: By acting on NK1 receptors in the central and peripheral nervous systems, ERP contributes to the modulation of pain transmission and neurogenic inflammation.
Vasodilation and Cardiovascular Effects: ERP influences vascular tone and permeability, contributing to its role in regulating blood flow and inflammatory responses.
Research Applications
ERP serves as a critical tool for studying tachykinin receptor pharmacology and the physiological roles of neuropeptides. It has been utilized to:
Investigate receptor-ligand interactions and signaling pathways associated with NK receptors.
Examine the roles of tachykinins in disorders such as irritable bowel syndrome (IBS), asthma, and inflammatory pain.
Explore therapeutic strategies targeting tachykinin receptors for managing pain, inflammation, and gastrointestinal dysfunction.
Conclusion
Eledoisin-related peptide is a potent neuropeptide that provides valuable insights into the roles of tachykinins in smooth muscle regulation, nociception, and inflammation. Its application in research enhances our understanding of neuropeptide biology and supports the development of receptor-targeted therapies for a range of pathological conditions.

Reference:

Faccia, M., Natrella, G., Gambacorta, G., & Trani, A. (2022). Cheese ripening in nonconventional conditions: A multiparameter study applied to Protected Geographical Indication Canestrato di Moliterno cheese. Journal of Dairy Science, 105(1), 140-153.