[Glu3]-RGES, Control for RGD Peptides

Product Name: [Glu3]-RGES, Control for RGD Peptides

Sequence One Letter Code: RGES

Sequence Three Letter Code: H-Arg-Gly-Glu-Ser-OH

Cas No: 93674-97-6

Chemical Formula:C16H29N7O8

Molecular Weight: 447.5

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: C(C[C@@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)N)CN=C(N)N

IUPAC: (4S)-4-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid

INCHIKEY: DJXDNYKQOZYOFK-GUBZILKMSA-N

INCHI:

InChI=1S/C16H29N7O8/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20)/t8-,9-,10-/m0/s1

Source / Species: synthetic

Conjugation: Unconjugated  

Code Nacres: NA.26

Application: [Glu³]-RGES is a control peptide designed for studies involving RGD-containing extracellular matrix and integrin-binding peptides. In this sequence, aspartic acid at position 3 of the RGDS motif is replaced by glutamic acid, altering biological activity and reducing integrin recognition. This substitution significantly decreases binding to extracellular matrix proteins, making [Glu³]-RGES useful as an inactive or low-activity control. The peptide is widely used to validate specificity in studies of cell adhesion, migration, integrin-mediated signaling, extracellular matrix interactions, angiogenesis, and RGD-dependent cellular responses in biomaterials and cell biology research.