Product Name:Syn-Coll
Cas No:623172-55-4
Purity:95%
Chemical Formula:C33H65N5O5
Molar Mass:611.9
Synonyms:Palmitoyl Tripeptide-5; palmitoyl-lysyl-valyl-lysine; SYN-COLL; 2A3916MQHO
IUPAC Name:(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid
SMILES:CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
InChIKey:LODWEXDBRZBADB-XEVVZDEMSA-N
InChI:InChI=1S/C33H65N5O5/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-23-29(39)36-27(21-17-19-24-34)31(40)38-30(26(2)3)32(41)37-28(33(42)43)22-18-20-25-35/h26-28,30H,4-25,34-35H2,1-3H3,(H,36,39)(H,37,41)(H,38,40)(H,42,43)/t27-,28-,30-/m0/s1
Storage:-20 degree Celsius
Sequence:KVK
Application:
Syn®-Coll (Palmitoyl Tripeptide-5) is a biomimetic signal peptide designed to stimulate the skin’s natural collagen production, improving firmness, elasticity, and wrinkle reduction. Composed of a three-amino-acid sequence conjugated to a palmitic acid chain for enhanced skin penetration, Syn-Coll interacts with the TGF-β pathway, promoting type I collagen synthesis while also inhibiting collagen-degrading enzymes like matrix metalloproteinases (MMPs). Clinically validated for its ability to reduce wrinkle depth, smooth fine lines, and improve dermal density, Syn-Coll is used in anti-aging serums, creams, and post-procedure skin repair products.
Current Research:
Introduction
Syn®-Coll, also known as Palmitoyl Tripeptide-5, is a synthetic signal peptide developed to address visible signs of skin aging by enhancing collagen biosynthesis and preserving extracellular matrix (ECM) integrity. It is composed of the amino acid sequence Val–Gly–Val attached to a palmitoyl group, which increases its lipophilicity and allows for efficient transdermal absorption.
Unlike traditional exfoliants or retinoids, Syn-Coll works by biomimicking natural skin signaling to promote regenerative processes at the cellular level, especially within fibroblasts.
Mechanism of Action: TGF-β Pathway Activation
Syn-Coll targets the Transforming Growth Factor Beta (TGF-β) pathway, a key signaling mechanism involved in collagen production and tissue regeneration. Once absorbed, Syn-Coll binds to TGF-β type II receptors in dermal fibroblasts, which:
Stimulates type I collagen synthesis
Enhances production of fibronectin and decorin, improving skin texture
Inhibits the activity of matrix metalloproteinases (MMPs), which break down collagen and elastin
By supporting both collagen production and protection, Syn-Coll creates an environment conducive to firmer, more elastic skin with reduced wrinkle depth.
Anti-Aging and Skin Rejuvenation Applications
Syn-Coll has been tested in in vivo and in vitro skin models, showing significant improvements in multiple age-related skin parameters:
Up to 350% increase in type I collagen in dermal fibroblast cultures
36% reduction in wrinkle depth after 4 weeks of topical application
Improvement in skin firmness and elasticity, measurable by cutometry and ultrasound
Enhanced skin hydration and texture without irritation
It is particularly effective in treating fine lines, crow’s feet, and nasolabial folds, making it a preferred ingredient in anti-aging formulations targeting mature or photoaged skin.
Skin Barrier and Post-Procedure Support
Syn-Coll also supports the restoration of the skin barrier, making it useful in post-laser, microneedling, or chemical peel recovery protocols. By enhancing dermal matrix remodeling and reducing inflammation, it aids in:
Faster re-epithelialization
Improved collagen alignment
Smoother skin surface recovery
It is gentle and well-tolerated, even when used with active ingredients like vitamin C, niacinamide, or hyaluronic acid.
Cosmetic Formulation and Use
Syn-Coll is stable in a wide pH range (4–7) and is water-soluble, allowing for seamless incorporation into:
Facial serums and moisturizers
Eye creams and neck firming gels
Anti-wrinkle masks and hydrogels
The typical concentration used in formulations ranges from 1–2.5%, providing optimal results with continued use over several weeks.
Its low molecular weight ensures deep dermal penetration, and it does not require encapsulation or special delivery systems for efficacy in most topical products.
Clinical Evaluation and Safety
Studies evaluating Syn-Coll have confirmed its non-toxic, non-irritating, and hypoallergenic properties. It does not induce photosensitivity or disrupt the skin microbiome. Human volunteers using Syn-Coll-containing formulations reported:
Noticeable reduction in wrinkle appearance
Improved skin density
No adverse reactions, even with long-term use
These outcomes support its role as a safe and effective bioactive in both daily skincare and advanced dermocosmetic treatments.
Conclusion
Syn®-Coll (Palmitoyl Tripeptide-5) is a scientifically advanced cosmetic peptide that stimulates natural collagen synthesis, protects against enzymatic degradation, and supports dermal structure renewal. With proven efficacy in wrinkle reduction, skin firming, and post-procedure repair, it is a staple ingredient in modern anti-aging skincare formulations. Its ability to restore youthful matrix architecture through biomimetic signaling makes it a go-to peptide for long-term skin health and visible rejuvenation.
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