Gonadorelin diacetate

Product Name:Gonadorelin diacetate

Form:Acetate salt

Purity:95%

Storage:-20^oC

Cas No:71447-49-9

Molar Mass:1302.4

Chemical Formula:C59H83N17O17

Synonyms:LHRH diacetate; UNII-7AT6GVO7OA

IUPAC Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide?

SMILES:CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O.CC(=O)O

InChIKey:QOVPLTBEZAJSHY-VIRDRFNDSA-N

InChI:InChI=1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1

Sequence:XHWSYGLRPG

Application:Gonadorelin diacetate is a synthetic analog of gonadotropin-releasing hormone (GnRH) that stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is primarily used in diagnosing and treating reproductive hormone deficiencies, such as hypogonadotropic hypogonadism and delayed puberty. Gonadorelin is also investigated for its role in assisted reproductive technologies (ART) and fertility treatments. Current research explores its potential applications in hormone replacement therapy (HRT), polycystic ovary syndrome (PCOS), and neuroendocrine regulation, offering broader therapeutic benefits in endocrinology, fertility, and metabolic disorders.

Current Research:Gonadorelin diacetate is a synthetic decapeptide that mimics natural gonadotropin-releasing hormone (GnRH), playing a crucial role in reproductive hormone regulation. It stimulates the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate testosterone, estrogen, and ovulation. While primarily used for diagnosing and treating reproductive disorders, emerging research is expanding its potential in fertility treatments, endocrine dysfunction, and neuroendocrine disorders. Endocrine and Reproductive Health Applications Gonadorelin diacetate is commonly used for diagnosing and treating gonadal hormone deficiencies. Hypogonadotropic hypogonadism: It is used to stimulate gonadotropin secretion in individuals with delayed puberty or low sex hormone production. Menstrual cycle regulation: Gonadorelin helps restore normal LH and FSH cycles in women with amenorrhea or irregular ovulation. Male infertility treatment: Research suggests it may improve spermatogenesis in men with hypogonadotropic hypogonadism-related infertility. Polycystic ovary syndrome (PCOS): Studies are exploring its role in modulating LH/FSH balance to improve ovulatory function in women with PCOS. Assisted Reproductive Technology (ART) and Fertility Research Gonadorelin diacetate is widely studied in fertility treatments and controlled ovarian stimulation protocols. Alternative to hCG in ovulation induction: Some research suggests Gonadorelin may be a safer alternative to human chorionic gonadotropin (hCG) in stimulating final oocyte maturation. Prevention of ovarian hyperstimulation syndrome (OHSS): By mimicking natural GnRH pulses, Gonadorelin reduces the risk of excessive ovarian stimulation during in vitro fertilization (IVF). Sperm maturation in men: Clinical trials are assessing its role in enhancing sperm count and motility in male infertility treatments. Neuroendocrine and Metabolic Research Beyond reproductive health, Gonadorelin is being explored for its effects on brain function and metabolic regulation. Neuroprotection in aging and neurodegeneration: Some studies suggest that GnRH agonists like Gonadorelin may have protective effects against Alzheimer??s disease and cognitive decline. Appetite and weight regulation: Research indicates potential roles in appetite control and metabolic syndrome, given its interactions with hypothalamic pathways. Hormone replacement therapy (HRT) and menopause: Gonadorelin is being investigated as an alternative therapy for hormone regulation in perimenopausal and postmenopausal women. Emerging Research Areas Endometriosis treatment: Gonadorelin??s ability to modulate estrogen levels makes it a candidate for endometriosis management. Testosterone regulation in aging men: Studies are assessing its role in treating late-onset hypogonadism without the risks of exogenous testosterone therapy. Chronic inflammatory and autoimmune disorders: Early research suggests GnRH analogs may influence immune responses, opening new avenues for treating chronic inflammatory diseases. With continued research, Gonadorelin diacetate is emerging as a versatile hormonal regulator, offering therapeutic potential in reproductive health, neuroendocrinology, and metabolic disorders.

Reference:Poock, S. E., Lamberson, W. R., & Lucy, M. C. (2015). Effect of different gonadorelin (GnRH) products used for the first or resynchronized timed artificial insemination on pregnancy rates in postpartum dairy cows. Theriogenology, 84(4), 504-508.