LF 11

Product Name:LF 11

CAS No:832729-13-2

Purity:95%

Molar Mass:1529.81

Chemical Formula:C69H112N26O14

Storage:Store at -20 degrees Celsius

Sequence:FQWQRNIRKVR

Application:LF 11 is a synthetic peptide derived from the antimicrobial peptide lactoferricin. Lactoferricin is a fragment of the larger glycoprotein lactoferrin, known for its broad-spectrum antimicrobial properties. LF 11 retains many of the antibacterial, antifungal, and antiviral activities of lactoferricin and is often used in research focused on host defense mechanisms, infection control, and immune modulation. LF 11 interacts with microbial membranes, leading to disruption of the membrane integrity, making it a valuable tool in studying antimicrobial resistance and the development of new therapeutic agents to combat infectious diseases. Additionally, LF 11 has been studied for its anti-cancer properties.

Current Research:

LF 11 (CAS: 832729-13-2) is an 11-amino acid peptide derived from the lipopolysaccharide (LPS)-binding region of human lactoferricin. It exhibits notable antimicrobial properties and the ability to neutralize endotoxins, making it a significant subject in biomedical research. Structural Composition The amino acid sequence of LF 11 is: Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-NH2 This sequence corresponds to the LPS-binding domain of human lactoferricin, a component of lactoferrin known for its antimicrobial activity. Antimicrobial Activity LF 11 demonstrates efficacy against both Gram-negative and Gram-positive bacteria. Its mechanism involves binding to bacterial LPS, leading to membrane disruption and bacterial cell death. This broad-spectrum activity positions LF 11 as a potential therapeutic agent in combating bacterial infections. Endotoxin Neutralization Beyond its bactericidal effects, LF 11 can neutralize endotoxins by binding to LPS, thereby inhibiting the pro-inflammatory responses typically induced by endotoxins. This property is particularly valuable in preventing or mitigating sepsis and other inflammatory conditions resulting from endotoxin exposure. Research Applications LF 11 serves as a model peptide in studies exploring antimicrobial mechanisms and endotoxin interactions. Its efficacy and specificity make it a useful tool in developing new antimicrobial therapies and understanding host-pathogen interactions.

Reference:

Sánchez-Gómez, S., Lamata, M., Leiva, J., Blondelle, S. E., Jerala, R., Andrä, J., … & Martínez-de-Tejada, G. (2008). Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC microbiology, 8, 1-9.