Litorin

Product Name:Litorin

CAS No:55749-97-8

Purity:95%

Molar Mass:1085.2

Chemical Formula:C51H68N14O11S

Storage:Store at -20 degrees Celsius

Sequence:XQWAVGHFM

Application:

Litorin is a neuropeptide belonging to the bombesin-like peptide family, initially isolated from the skin of the frog species Litoria aurea. Comprising 10 amino acids, Litorin shares structural similarities with other bombesin-like peptides and exhibits a range of biological activities, including stimulating the release of gastrointestinal hormones, modulating smooth muscle contraction, and influencing central nervous system functions. In research, Litorin is utilized to study its effects on receptor interactions, particularly with the bombesin receptor, and its role in various physiological processes. This peptide is valuable for investigating potential therapeutic applications in gastrointestinal disorders, cancer, and neurological conditions.

Current Research:

Litorin is a 10-amino acid neuropeptide belonging to the bombesin-like peptide family, originally isolated from the skin of amphibians such as Litoria aurea. Its sequence is Gly-Leu-Met-Tyr-Pro-Arg-His-Ala-Trp-Ala-NH?, closely resembling the structure of bombesin. Litorin interacts with bombesin receptors (BB receptors) and is known for its potent effects on smooth muscle contraction, secretion, and thermoregulation.
Physiological Roles
Smooth Muscle Contraction: Litorin induces contractions in gastrointestinal and vascular smooth muscles, similar to other bombesin-like peptides, contributing to its regulatory role in gut motility and cardiovascular tone.
Secretion Stimulation: It enhances the secretion of digestive enzymes and hormones, playing a role in digestive processes.
Central Nervous System Activity: Litorin influences thermoregulation and feeding behavior, acting via receptors in the brain to modulate body temperature and appetite.
Potential Endocrine Roles: Its structural similarity to bombesin suggests involvement in endocrine regulation, including the modulation of growth hormone and insulin release.
Research Implications
Litorin serves as a valuable tool in studies exploring the roles of bombesin-like peptides in physiological and pathological conditions. It has been used to investigate receptor-ligand interactions, smooth muscle pharmacology, and the mechanisms underlying thermoregulation and appetite control. Additionally, its ability to bind to bombesin receptors makes it a candidate for research into cancer, as these receptors are overexpressed in certain tumors, including small cell lung carcinoma and prostate cancer.
Conclusion
Litorin, a bombesin-like peptide, is integral to understanding the complex roles of neuropeptides in smooth muscle function, central nervous system regulation, and endocrine signaling. Its study advances our knowledge of peptide-mediated processes and supports the development of therapeutic applications targeting related pathways.

Reference:

Cline, M. A., Cofield, S. A., & Tachibana, T. (2010). Central litorin injection is associated with primary anorexigenic effects that coincide with activation of the magnocellular division of the paraventricular nucleus. Neuropeptides, 44(3), 247-252.