[Lys(Ac)12/16]-Histone H4 (1-25)-GSGSK(Biotin)

Product Name: [Lys(Ac)12/16]-Histone H4 (1-25)-GSGSK(Biotin)

Sequence One Letter Code: SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHRKVLRDN-GSGSK(Biotin)

Sequence Three Letter Code: H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH

Molecular Weight: 3317

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: Histone H4 (1–25), K12ac/K16ac-Biotin is a synthetic histone H4 peptide diacetylated at lysines 12 and 16, two important regulatory sites involved in chromatin remodeling and transcriptional control. Sequential acetylation of H4K16 followed by H4K12 is associated with altered chromatin accessibility and protein recruitment. Diacetylated H4 interacts with transcriptional regulators such as TUP1 and bromodomain-containing proteins, while modulating heterochromatin-related interactions. The biotinylated linker enables affinity capture, pull-down, and binding assays. This peptide is widely used in epigenetics research to study histone acetylation crosstalk and chromatin-associated protein interactions.