[Lys(Ac)56]-Histone H3 (44-63)

Product Name: [Lys(Ac)56]-Histone H3 (44-63)

Sequence One Letter Code: GTVALREIRRYQ-K(Ac)-STELLIR

Sequence Three Letter Code: H-Gly-Thr-Val-Ala-Leu-Arg-Glu-Ile-Arg-Arg-Tyr-Gln-Lys(Ac)-Ser-Thr-Glu-Leu-Leu-Ile-Arg-OH

Molecular Weight: 2445

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: [Lys(Ac)56]-Histone H3 (44–63) is a synthetic histone H3 peptide acetylated at lysine 56, a modification associated with DNA replication, chromatin assembly, and genome stability. H3K56 acetylation occurs during S phase and persists through DNA damage repair, supporting replisome integrity and replication-coupled chromatin regulation. This mark is catalyzed by the Rtt109–Vps75 histone acetyltransferase complex, and loss of H3K56 acetylation has been linked to chromosome instability and spontaneous DNA breaks. This peptide is widely used to study DNA damage response, replication-associated chromatin assembly, and acetylation-dependent epigenetic regulation.