[Lys(Me1)12]-Histone H4(1-21)-GGK(Biotin)

Product Name: [Lys(Me1)12]-Histone H4(1-21)-GGK(Biotin)

Sequence One Letter Code: Ac-SGRGKGGKGLG-K(Me1)-GGAKRHRKV-GGK(Biotin)

Sequence Three Letter Code: Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Me1)-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2616.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Lys(Me1)12]-Histone H4 (1–21)-GGK(Biotin) is a synthetic N-terminal histone H4 peptide monomethylated at lysine 12 and modified with a C-terminal GG linker plus biotinylated lysine. H4K12 monomethylation has been linked to chromatin organization, transcriptional regulation, and modification-dependent protein recognition. The biotin tag enables affinity-based detection, immobilization, pull-down assays, and binding studies using streptavidin systems. This modified histone peptide is commonly used in epigenetics research to study lysine methyltransferase specificity, histone reader interactions, chromatin-associated signaling pathways, and the role of H4K12 methylation in gene regulation.