[Lys(Me3)36]-Histone H3 (21-44)-GK(Biotin)

Product Name: [Lys(Me3)36]-Histone H3 (21-44)-GK(Biotin)

Sequence One Letter Code: ATKAARKSAPATGGV-K(Me3)-KPHRYRPG-GK(Biotin)

Sequence Three Letter Code: H-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys(Me3)-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2960.7

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Lys(Me3)36]-Histone H3 (21–44)-GK(Biotin) is a synthetic histone H3 peptide trimethylated at lysine 36, a hallmark of actively transcribed gene bodies. H3K36me3 is enriched over exons and has been implicated in exon definition, alternative splicing regulation, transcription elongation, and chromatin-associated RNA processing. The modification also serves as a recruitment signal for histone deacetylases and other chromatin regulators. The biotinylated C-terminus enables pull-down, binding, and interaction assays. This peptide is widely used to study transcription-coupled chromatin modification, methyl-lysine recognition, RNA processing, and active gene regulation.