[Lys(Me3)4]-Histone H3 (1-21)

Product Name: [Lys(Me3)4]-Histone H3 (1-21)

Sequence One Letter Code: ART-K(Me3)-QTARKSTGGKAPRKQLA

Sequence Three Letter Code: H-Ala-Arg-Thr-Lys(Me3)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-OH

Molecular Weight: 2297.8

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: [Lys(Me3)4]-Histone H3 (1–21) is a synthetic histone H3 N-terminal peptide trimethylated at lysine 4, a hallmark of transcriptionally active chromatin. H3K4me3 is highly enriched at transcription start sites and contributes to recruitment of transcriptional machinery and chromatin-associated regulatory proteins. This modification is dynamically regulated by histone methyltransferases and demethylases, including KDM5 family enzymes. [Lys(Me3)4]-Histone H3 (1–21) is widely used in epigenetics research to study chromatin recognition, methyl-lysine reader proteins, transcription initiation, enzyme specificity, histone methylation dynamics, and active promoter regulation.