MBP (88-104), guinea pig, MBP (89-105), human, MBP (86-102), mouse

Product Name: MBP (88-104), guinea pig, MBP (89-105), human, MBP (86-102), mouse

Sequence One Letter Code: Ac-FFKNIVTPRTPPPSQGK-NH2

Sequence Three Letter Code: Ac-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro-Ser-Gln-Gly-Lys-NH2

Chemical Formula:C91H143N25O23

Molecular Weight: 1955.4

Purity: 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Research Area: Neurological Disease Research

Source / Species: guinea pig, human, mouse

Conjugation: Unconjugated

Code Nacres: NA.26

Application: This peptide corresponds to a conserved fragment of myelin basic protein (MBP), mapping to residues 88–104 in guinea pig, 89–105 in human, and 86–102 in mouse, and features N-terminal acetylation. MBP is a major structural component of the myelin sheath in the central nervous system and plays an essential role in maintaining myelin integrity and stability. The sequence represented by this peptide contains immunodominant epitopes that are frequently recognized by autoreactive T cells in autoimmune demyelinating diseases. As a result, it is widely used in experimental models of neuroinflammation and autoimmune pathology. This MBP peptide is commonly applied in studies investigating T-cell responses, antigen presentation, and immune mechanisms underlying multiple sclerosis and other demyelinating disorders, making it an important reagent for immunological and neurological research.

Current Research: Myelin basic protein (MBP) is one of the most abundant structural proteins in the myelin sheath of the central nervous system (CNS). It plays a crucial role in maintaining the compact structure of myelin, which insulates axons and enables rapid nerve signal transmission. Fragments derived from MBP have been widely studied because certain regions of the protein contain immunodominant epitopes capable of triggering autoreactive immune responses. One particularly important fragment corresponds to MBP residues 88–104 in guinea pig, 89–105 in human, and 86–102 in mouse, and is typically synthesized with N-terminal acetylation to mimic its native structural context. This peptide segment has been extensively used in immunological and neurological research because it contains epitopes frequently recognized by autoreactive T cells involved in autoimmune demyelinating diseases, including multiple sclerosis (MS). Myelin Basic Protein and Myelin Stability The myelin sheath is a multilayered membrane structure that surrounds axons in the central nervous system. It is essential for maintaining efficient neuronal communication by enabling saltatory conduction, a process that allows electrical signals to travel rapidly along nerve fibers. MBP contributes significantly to the formation and stability of this sheath. It functions by interacting with the cytoplasmic surfaces of myelin membranes, promoting close membrane apposition and maintaining the compact structure of myelin. Because of this structural role, disruptions in MBP expression or immune recognition of MBP-derived peptides can lead to myelin damage and impaired neural signaling. Conserved Immunodominant Epitope The MBP peptide fragment described here corresponds to a highly conserved sequence across multiple species, including guinea pig, human, and mouse. This conservation highlights the functional importance of the region within the MBP protein. Importantly, this sequence contains immunodominant T-cell epitopes that are recognized by autoreactive CD4⁺ T cells in various models of autoimmune demyelination. These epitopes are capable of binding major histocompatibility complex (MHC) molecules and being presented to T cells, initiating immune responses that target myelin components. Because of these properties, the MBP fragment serves as a powerful experimental antigen for studying immune recognition of myelin proteins. Role in Experimental Autoimmune Encephalomyelitis (EAE) One of the most widely used applications of MBP peptides is in the study of experimental autoimmune encephalomyelitis (EAE). EAE is a well-established animal model used to investigate the immunological and pathological mechanisms of multiple sclerosis. In EAE research, MBP-derived peptides are used to induce autoimmune responses against myelin in laboratory animals. These models allow scientists to examine: Activation of autoreactive T cells Immune cell infiltration into the central nervous system Demyelination and neuroinflammation Cytokine signaling and immune regulation Because the MBP 88–104 region contains a strong T-cell epitope, it is particularly useful for generating reproducible immune responses in experimental systems. Studying T-Cell Responses and Antigen Presentation The MBP peptide fragment is also widely used in immunological assays designed to analyze T-cell activation and antigen presentation mechanisms. When presented by antigen-presenting cells through MHC class II molecules, this peptide can stimulate autoreactive T cells that recognize myelin antigens. Researchers frequently use this peptide to investigate: T-cell receptor recognition of myelin epitopes Antigen processing and presentation pathways Cytokine secretion profiles of activated immune cells Immune tolerance and regulatory T-cell activity These experiments help clarify how the immune system distinguishes between self and non-self antigens and how breakdowns in immune tolerance contribute to autoimmune disease. Relevance to Multiple Sclerosis Research Multiple sclerosis is a chronic autoimmune disease characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Although the exact causes of MS remain complex and multifactorial, autoreactive immune responses against myelin proteins—including MBP—are believed to play a significant role. MBP-derived peptides such as this conserved fragment are therefore widely used to explore the immune mechanisms underlying MS, including the activation of pathogenic T cells and the inflammatory processes that lead to myelin damage. Through controlled experimental models, scientists can investigate how immune responses against MBP contribute to disease development and how immune pathways might be modulated to reduce neuroinflammation. A Valuable Peptide for Neuroimmunology Studies Due to its conserved structure and immunological relevance, this MBP peptide has become a widely used reagent in neuroimmunology and autoimmune disease research. It enables researchers to examine fundamental processes such as antigen recognition, immune activation, and inflammatory signaling within the central nervous system. Applications commonly include: Experimental models of autoimmune demyelination T-cell activation assays Studies of antigen presentation and immune tolerance Investigations into the mechanisms of neuroinflammation Conclusion The MBP peptide corresponding to residues 88–104 in guinea pig, 89–105 in human, and 86–102 in mouse, with N-terminal acetylation, represents a conserved and immunologically significant fragment of myelin basic protein. Because it contains a well-characterized T-cell epitope, the peptide is widely used in experimental models exploring autoimmune demyelination, neuroinflammation, and immune responses to myelin antigens. By enabling detailed investigation of T-cell activation and antigen presentation, this peptide continues to play an important role in advancing research into multiple sclerosis and other demyelinating disorders, contributing to a deeper understanding of the immune mechanisms that affect the central nervous system.