Neurokinin B (human, porcine)

Product Name:Neurokinin B (human, porcine)

Synonyms:NEUROKININ K

CAS No:86933-75-7

Purity:95%

Molar Mass:1210.4

Chemical Formula:C55H79N13O14S2

Storage:Store at -20 degrees Celsius

Sequence:DMHDFFVGLM

Target:NK3R

Application:

Neurokinin B (human, porcine) is a conserved tachykinin peptide that binds to the neurokinin-3 receptor (NK3R), playing a critical role in reproductive physiology. It is involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion, making it essential for normal reproductive function. Beyond reproduction, Neurokinin B influences body temperature, mood, and stress responses. Due to its involvement in these processes, this peptide is widely used in research to explore conditions such as polycystic ovary syndrome (PCOS), menopausal hot flashes, and other reproductive disorders, providing insights that could lead to new therapeutic strategies for these conditions.

Current Research:

Neurokinin B (NKB), a member of the tachykinin family of neuropeptides, is found in both human and porcine species. It is encoded by the TAC3 gene and interacts primarily with the neurokinin-3 receptor (NK3R), playing a pivotal role in neuroendocrine and central nervous system functions. NKB consists of a conserved decapeptide sequence critical for its receptor-binding activity.
Biological Functions and Mechanisms
Neurokinin B is integral to the regulation of reproductive physiology. It is expressed in hypothalamic neurons that influence the release of gonadotropin-releasing hormone (GnRH), thus modulating the hypothalamic-pituitary-gonadal (HPG) axis. NKB is also involved in thermoregulation, stress responses, and nociception, contributing to various physiological and pathophysiological processes.
Clinical and Research Applications
Reproductive Disorders: Dysregulation of NKB signaling is linked to conditions such as hypogonadotropic hypogonadism. Research into NKB and NK3R antagonists or agonists is ongoing for potential therapies in fertility management.
Menopausal Symptoms: NKB's role in thermoregulation has made it a target for developing treatments for hot flashes in menopausal women.
Neurological Studies: NKB serves as a model for understanding the tachykinin system's involvement in neurodegenerative diseases, mood disorders, and pain modulation.
Comparative Studies: The similarity in NKB structure between humans and porcine species makes it valuable for cross-species studies, especially in translational research.
Emerging Research
Recent studies highlight the involvement of NKB in metabolic pathways and energy homeostasis. Its interplay with other neuropeptides and hormones suggests broader implications in obesity and metabolic syndrome.
Neurokinin B (human, porcine) remains a crucial tool in biomedical research, shedding light on complex neuroendocrine pathways and offering new therapeutic targets for a range of disorders.

Reference:

Thorson, J. F., Prezotto, L. D., Adams, H., Petersen, S. L., Clapper, J. A., Wright, E. C., ... & Lents, C. A. (2018). Energy balance affects pulsatile secretion of luteinizing hormone from the adenohypophesis and expression of neurokinin B in the hypothalamus of ovariectomized gilts. Biology of Reproduction, 99(2), 433-445.