Neuromedin B (porcine)

Product Name:Neuromedin B (porcine)

Synonyms:Gly-asn-leu-trp-ala-thr-gly-his-phe-met-NH2

CAS No:87096-84-2

Purity:95%

Molar Mass:1132.3

Chemical Formula:C52H73N15O12S

Storage:Store at -20 degrees Celsius

Sequence:GNLWATGHFM

Target:neuromedin B receptor (NMBR)

Application:

Neuromedin B (porcine) is a 10-amino acid peptide belonging to the bombesin-like peptide family, originally isolated from porcine spinal cord tissue. This neuropeptide acts as an endogenous ligand for the neuromedin B receptor (NMBR), playing a significant role in regulating various physiological processes, including thermoregulation, smooth muscle contraction, and the release of pituitary hormones. Neuromedin B is also involved in modulating feeding behavior and energy homeostasis. Due to its diverse biological activities, this peptide is widely utilized in research focused on understanding its receptor interactions, signaling pathways, and potential therapeutic targets for conditions such as obesity, cancer, and gastrointestinal disorders.

Current Research:

Neuromedin B (NMB) is an endogenous decapeptide belonging to the bombesin-like peptide family, initially identified in porcine spinal cord. It is characterized by its amino acid sequence, Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH?. NMB binds with high affinity to the neuromedin B receptor (NMBR), a G protein-coupled receptor, activating intracellular signaling pathways that influence multiple physiological processes.
Physiological Roles
NMB plays critical roles in several biological systems:
Endocrine and Exocrine Regulation: It modulates the secretion of hormones and digestive enzymes, contributing to the regulation of metabolic processes.
Smooth Muscle Contraction: It induces smooth muscle contractions, influencing gastrointestinal motility and vascular tone.
Thermoregulation: It is involved in maintaining body temperature homeostasis.
Appetite Control: It regulates feeding behavior through central mechanisms, affecting appetite and food intake.
Cellular Growth and Proliferation: It supports cellular growth, with implications for both normal tissue maintenance and pathological states such as cancer.
Clinical Implications
NMB's diverse functions make it a significant molecule in physiological and pathological contexts. Dysregulated NMB signaling has been linked to conditions such as metabolic disorders, gastrointestinal dysfunctions, and certain cancers. These associations highlight its potential as a therapeutic target for managing these diseases.
In summary, Neuromedin B is a versatile peptide influencing critical bodily functions, including digestion, thermoregulation, and cell proliferation. Its study continues to reveal insights into its mechanisms and therapeutic applications.

Reference:

Ohki-Hamazaki, H. (2016). Neuromedin B. In Handbook of Hormones (pp. 193-e22B). Academic Press.