Neuropeptide SF (mouse, rat)

Product Name:Neuropeptide SF (mouse, rat)

CAS No:230960-31-3

Purity:95%

Molar Mass:888.03

Chemical Formula:C40H65N13O10

Storage:Store at -20 degrees Celsius

Sequence:SLAAPQRF

Target:neuropeptide FF

Application:

Neuropeptide SF (NP SF) is a peptide that functions as a neuromodulator and is involved in various physiological processes. In both mice and rats, Neuropeptide SF is known to interact with specific G protein-coupled receptors to influence feeding behavior, stress responses, and neuroendocrine regulation. It plays a role in modulating neurotransmission and has been studied for its effects on appetite regulation and energy homeostasis. Research on Neuropeptide SF in these animal models helps to understand its mechanisms and potential therapeutic applications for disorders related to appetite control and stress.

Current Research:

Neuropeptide SF (NPSF), derived from the precursor protein proSAAS, has emerged as a significant focus in neurobiological and pharmaceutical research. In rodents, NPSF exhibits regulatory effects on diverse physiological processes, including pain modulation, appetite control, and stress response. Its involvement in these critical pathways has highlighted its potential as a target for therapeutic intervention in various neurological and metabolic disorders. NPSF exerts its effects through the modulation of G-protein-coupled receptors, particularly influencing the opioid and neuropeptide systems. Studies in mouse and rat models reveal that NPSF has anti-opioid activity, counteracting the analgesic effects of endogenous and exogenous opioids. This unique property suggests its role in fine-tuning the pain response and offers insights into managing opioid tolerance and addiction. Another area of interest is NPSF's contribution to appetite regulation. Research indicates that NPSF can act as an anorexigenic peptide, suppressing food intake in rodents. These findings position NPSF as a potential target for obesity and metabolic syndrome treatments. Furthermore, its influence on the hypothalamic-pituitary-adrenal axis underscores its importance in stress-related disorders. Preclinical investigations have also shed light on NPSF's involvement in neuroendocrine regulation and circadian rhythm maintenance. Emerging studies are exploring its neuroprotective effects in conditions such as neurodegeneration and cognitive decline. However, the precise mechanisms underlying these effects remain an active area of investigation. The development of synthetic analogs and receptor-specific modulators of NPSF is ongoing, aiming to enhance its therapeutic potential. These efforts are supported by advancements in peptide delivery systems to improve bioavailability and stability. Neuropeptide SF represents a promising avenue in neuroscience and endocrinology, warranting further research to fully elucidate its physiological and pathological roles.

Reference:

Jászberényi, M., Bagosi, Z., Csabafi, K., Palotai, M., & Telegdy, G. (2014). The actions of neuropeptide SF on the hypothalamic–pituitary–adrenal axis and behavior in rats. Regulatory peptides, 188, 46-51.