Neurotensin Peptide

Product Name: Neurotensin Peptide

Sequence One Letter Code: Pyr-LYENKPRRPYIL

Sequence Three Letter Code: Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

Cas No: 55508-42-4

Chemical Formula:C78H121N21O20

Molecular Weight: 1673

Purity: 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Research Area: Neurological Disease Research

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5

IUPAC: (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid

INCHIKEY: PCJGZPGTCUMMOT-ISULXFBGSA-N

INCHI:

InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1

Source / Species: human, rat, bovine, mouse

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Neurotensin is a 13-amino-acid neuropeptide widely distributed in the central nervous system and peripheral tissues, particularly in the gastrointestinal tract. It contains an N-terminal pyroglutamic acid residue and functions as a neuromodulator and hormone. In the brain, neurotensin regulates dopaminergic signaling, influences anterior pituitary hormone release, and exhibits hypothermic and analgesic effects. In peripheral tissues, it induces smooth muscle contraction and modulates gastrointestinal activity. Neurotensin is implicated in various neurological and psychiatric disorders and is widely used in research to study neurotransmission, neuroendocrine regulation, and receptor-mediated signaling pathways.

Current Research: Neurotensin is a 13-amino-acid neuropeptide that functions as both a neuromodulator and peripheral hormone, with widespread distribution in the central nervous system (CNS) and gastrointestinal tract. Structurally, it is characterized by an N-terminal pyroglutamic acid residue, which contributes to its stability and biological activity. Neurotensin plays a significant role in neurotransmission, endocrine regulation, and smooth muscle function, making it an important molecule in both physiological and pathological research. Structural Features and Receptor Interaction Neurotensin exerts its effects through binding to neurotensin receptors (NTSRs), primarily: NTSR1 and NTSR2 – G protein–coupled receptors mediating most physiological responses NTSR3 (sortilin) – involved in intracellular trafficking and signaling modulation The C-terminal region (residues 8–13) is critical for receptor binding and activation, and truncated analogues of this region often retain biological activity. Role in Central Nervous System Function In the CNS, neurotensin is involved in modulating several key neurotransmitter systems, particularly dopaminergic signaling. It is highly expressed in brain regions such as the hypothalamus, amygdala, and mesolimbic pathways, where it influences: Dopamine transmission, including modulation of D2 receptor signaling Regulation of anterior pituitary hormone release Thermoregulation, often inducing hypothermic responses Analgesic effects, contributing to pain modulation Through these actions, neurotensin plays a role in behavioral regulation, stress response, and neuroendocrine integration. Functions in Peripheral Tissues Outside the CNS, neurotensin acts as a hormone in the gastrointestinal system, where it is released by enteroendocrine cells in response to food intake, particularly dietary fats. Its peripheral effects include: Stimulation of smooth muscle contraction Regulation of intestinal motility Modulation of gastric and pancreatic secretions Influence on blood flow in the digestive tract These actions contribute to the coordination of digestive processes and nutrient absorption. Neurotensin in Neuroendocrine Regulation Neurotensin also plays a role in neuroendocrine signaling, linking the nervous system with hormonal responses. It can influence: Release of pituitary hormones Interactions between hypothalamic and peripheral endocrine systems Feedback mechanisms involved in metabolic regulation This integrative function highlights its importance in maintaining homeostasis across multiple physiological systems. Implications in Neurological and Psychiatric Disorders Alterations in neurotensin signaling have been associated with a range of neurological and psychiatric conditions, including: Schizophrenia and dopamine-related disorders Parkinson’s disease Pain disorders Addiction and reward pathway dysregulation Because of its interaction with dopaminergic pathways, neurotensin is often studied as a modulator of neuropsychiatric function and behavior. Applications in Research Neurotensin is widely used as a model peptide in studies of neurotransmission, receptor signaling, and hormone regulation. Common research applications include: Investigation of GPCR signaling via neurotensin receptors Studies of dopamine–neuropeptide interactions Analysis of pain modulation and analgesic pathways Research on gastrointestinal motility and secretion Exploration of neuroendocrine communication mechanisms Its diverse biological roles make it a valuable tool for examining cross-talk between neural and endocrine systems. A Versatile Tool for Studying Neurotransmission and Hormonal Signaling Neurotensin is a multifunctional peptide that bridges central nervous system activity and peripheral physiological processes. Its involvement in dopaminergic modulation, hormone secretion, and gastrointestinal function underscores its importance in both basic and translational research. By enabling detailed investigation of receptor-mediated signaling, neuroendocrine regulation, and neuromodulatory pathways, neurotensin continues to contribute to advances in understanding brain function, metabolic control, and disease-related signaling mechanisms.