NFAT Inhibitor

Product Name: NFAT Inhibitor

CAS No: 249537-73-3

Purity: 95%

Molar Mass: 1683.9

Chemical Formula: C75H118N20O22S

Storage: Store at -20 degrees Celsius

Sequence: MAGPHPVIVITGPHEE

Target: NFAT

Application:

NFAT Inhibitor is a peptide designed to inhibit the Nuclear Factor of Activated T-cells (NFAT) signaling pathway. By preventing the activation and nuclear translocation of NFAT proteins, this inhibitor suppresses the transcription of genes involved in immune response and inflammation. It is primarily used in immunological research to study T-cell activation, autoimmune diseases, and inflammatory processes. Additionally, NFAT Inhibitor is explored in therapeutic research for conditions such as transplant rejection, rheumatoid arthritis, and other chronic inflammatory diseases, aiming to develop treatments that modulate immune function.

Current Research:

The NFAT Inhibitor, commonly referred to as the VIVIT peptide, is a synthetic peptide designed to selectively inhibit the calcineurin-mediated dephosphorylation of Nuclear Factor of Activated T cells (NFAT). By specifically targeting the interaction between calcineurin and NFAT, this inhibitor effectively suppresses NFAT activation without disrupting other calcineurin-dependent pathways. In immunological studies, the NFAT Inhibitor has been instrumental in elucidating the role of NFAT in T-cell function. Its application has demonstrated a significant reduction in the expression of cytokine genes dependent on NFAT, thereby providing insights into T-cell activation and differentiation processes. Beyond immunology, this inhibitor has been utilized in neurological research to investigate microglial activity. Studies have shown that inhibiting NFAT signaling in microglia can modulate their phenotype, suggesting potential therapeutic avenues for neuroinflammatory conditions. The specificity of the NFAT Inhibitor for the calcineurin-NFAT interaction makes it a valuable tool in pharmacological research. It allows for the precise dissection of NFAT's role in various cellular processes, facilitating the development of targeted therapies for diseases where NFAT signaling is dysregulated. In summary, the NFAT Inhibitor (VIVIT peptide) serves as a potent and selective modulator of NFAT activation. Its application across multiple research domains continues to advance our understanding of calcineurin-NFAT signaling and its implications in health and disease.

Reference:

Martínez-Martínez, S., & Redondo, J. M. (2004). Inhibitors of the calcineurin/NFAT pathway. Current medicinal chemistry, 11(8), 997-1007.