Product Name: Oligopeptide-24 (EGF-like peptide)
Cas No: 1018685-16-9
Purity: 95%
Storage: Keep in dark and cool dry place -5~8 degree Celsius
Sequence: H-Cys-Met-Tyr-Ile-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Gly-OH
Molar Mass: 1271.4
Chemical Formula: C50H78N16O19S2
Synonyms: CG-EDP3; orb1943151; HY-P5257; CS-0863886
IUPAC Name: (4S)-4-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-5-[[2-[[2-[[2-[[2-[[(2S)-1-[[2-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)N
InChIKey: KETLMQUWYBBGQR-ZXVPBAOPSA-N
InChI: InChI=1S/C50H78N16O19S2/c1-4-25(2)42(66-48(84)32(16-26-7-9-27(67)10-8-26)65-47(83)31(13-15-87-3)63-43(79)28(51)24-86)49(85)64-30(11-12-39(73)74)45(81)58-20-36(70)56-18-34(68)55-19-35(69)57-21-37(71)61-29(6-5-14-54-50(52)53)44(80)59-22-38(72)62-33(17-40(75)76)46(82)60-23-41(77)78/h7-10,25,28-33,42,67,86H,4-6,11-24,51H2,1-3H3,(H,55,68)(H,56,70)(H,57,69)(H,58,81)(H,59,80)(H,60,82)(H,61,71)(H,62,72)(H,63,79)(H,64,85)(H,65,83)(H,66,84)(H,73,74)(H,75,76)(H,77,78)(H4,52,53,54)/t25-,28-,29-,30-,31-,32-,33-,42-/m0/s1
Application:
Oligopeptide-24 (EGF-like Peptide) is a biomimetic growth factor–inspired peptide designed to support visible skin renewal, firmness, and rejuvenation. By mimicking natural epidermal signaling, it helps promote improved cell turnover, smoother texture, and enhanced elasticity. In cosmetic research, Oligopeptide-24 is widely used to explore reduced fine lines, increased skin density, and a brighter, revitalized complexion. Its stable, low–molecular weight structure allows effective activity in serums, ampoules, and advanced anti-aging treatments. Ideal for formulations targeting dullness and early to advanced signs of aging, this peptide delivers a refined, youthful-looking appearance through boosted regenerative performance.
Current Research:
Oligopeptide-24 (EGF-like Peptide): Research Overview
Oligopeptide-24 (also known as CG-EDP3 and sometimes described as an “EGF-like peptide”) is a synthetic 13–amino-acid elastin-derived peptide developed as a biomimetic regulator of skin cell renewal and extracellular matrix (ECM) synthesis. Its reported sequence is CMYIEGGGGRGDG, with a molecular weight of approximately 1271 Da. This low molecular weight places it comfortably below the common 500–1000 Da practical threshold used when considering topical diffusion, while still large enough to participate in specific receptor-mediated interactions.
Oligopeptide-24 is a linear oligopeptide built from cysteine, methionine, tyrosine, isoleucine, glutamic acid, multiple glycine residues, arginine, and aspartic acid.
Key structural features:
Glycine-rich core (several consecutive Gly residues) providing flexibility and allowing the peptide to adopt conformations suitable for receptor binding.
Acidic (Glu, Asp) and basic (Arg) residues, supporting electrostatic interactions with cell-surface receptors and matrix components.
Cysteine at the N-terminus, offering potential for disulfide participation or anchoring within supramolecular structures.
It is described in technical literature as an elastin-derived peptide and EGF-like biomimetic, because its signaling profile overlaps with pathways influenced by epidermal growth factor (EGF) and ECM fragments.
Oligopeptide-24 is characterized as a peptide that upregulates EGF expression and stimulates skin cell proliferation, migration, and survival in vitro. Rather than being a direct EGF receptor agonist, it acts upstream at the level of growth-factor production and related signaling cascades. Reported activities in skin-cell models include:
Increased EGF production in fibroblasts under serum-free conditions.
Promotion of cell growth and migration in keratinocytes and fibroblasts.
Support of cell survival under culture stress, suggesting engagement of pro-survival signaling networks.
Through these mechanisms, Oligopeptide-24 is positioned as a cell-renewal and repair regulator, indirectly echoing EGF-associated pathways without being a full-length growth factor.
A major focus in cosmetic research is the impact of Oligopeptide-24 on dermal ECM components and associated hydration molecules. In fibroblast models, it has been reported to:
Increase hyaluronic acid (HA) production up to about threefold, in a dose-dependent manner.
Upregulate elastin expression, with approximately 1.3-fold increases under some experimental conditions.
Promote synthesis of other ECM constituents such as collagen and fibronectin according to broader biomimetic-peptide studies that include CG-EDP3.
These changes support the concept that Oligopeptide-24 functions as an ECM-active peptide, stimulating both structural proteins (collagen, elastin) and matrix hydrators (HA).
Mechanistically, Oligopeptide-24 is thought to:
Bind to cell-surface receptors on fibroblasts and possibly keratinocytes, activating intracellular signaling cascades relevant to proliferation and matrix synthesis.
Enhance expression of growth factors, particularly EGF, which in turn modulate epidermal and dermal cell behavior.
Boost ECM biosynthesis, leading to higher levels of elastin and HA and, in some data sets, collagen and fibronectin.
Because elastin-derived sequences naturally act as matrikines in tissue remodeling, Oligopeptide-24 is often framed as a synthetic matrikine analogue designed to amplify repair and renewal signals in aged or stressed skin.
In cosmetic and cosmeceutical applications, Oligopeptide-24 has been integrated into anti-aging and repair-focused formulations. Reported biological effects relevant to these uses include:
Improved fibroblast activity and proliferation, providing higher cellular capacity for ECM maintenance.
Support of skin firmness and density, inferred from increased elastin and HA and from its classification among firming/anti-wrinkle actives.
General skin-repair activity, with descriptions highlighting its role in enhancing structural protein synthesis following stress or injury in experimental models.
These properties place Oligopeptide-24 among multifunctional cosmetic peptides that simultaneously address cell renewal, matrix quantity, and matrix quality.
Technical data describe Oligopeptide-24 as:
A lyophilized powder of high purity, stored at low temperature and protected from light and moisture.
Water-soluble or soluble in common polar solvents, suitable for incorporation into aqueous phases of serums, gels, and emulsions.
Typically used at low concentrations characteristic of signal peptides, with attention to cool-down addition and antioxidant support to maintain peptide integrity during shelf life.
It is also mentioned as suitable for hair- and lash-related formulations, where the same proliferative and ECM-supporting mechanisms can be applied to hair-follicle–adjacent structures.
Summary
Oligopeptide-24 (EGF-like peptide/CG-EDP3) is a 13-residue elastin-derived biomimetic peptide characterized by EGF upregulation, stimulation of fibroblast proliferation and migration, and enhanced synthesis of elastin, hyaluronic acid, and other ECM components in skin-cell models. Through these combined activities, it is studied as a cell-renewal and matrix-support peptide relevant to firmness, density, and repair-oriented cosmetic research.
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