OVA-G4 Peptide, SIIGFEKL, OVA (257-264) Variant

Product Name: OVA-G4 Peptide, SIIGFEKL, OVA (257-264) Variant

Sequence One Letter Code: SIIGFEKL

Sequence Three Letter Code: H-Ser-Ile-Ile-Gly-Phe-Glu-Lys-Leu-OH

Chemical Formula:C43H71N9O12

Molecular Weight: 906.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: chicken

Conjugation: Unconjugated

Code Nacres: NA.26

Application: OVA-G4 (SIIGFEKL) is a single-amino-acid variant of the canonical ovalbumin epitope SIINFEKL, a well-characterized MHC class I-restricted peptide presented by the murine H-2Kᵇ molecule. The substitution at position 4 alters T-cell receptor engagement while preserving MHC binding, making this peptide valuable for studying antigen recognition and T-cell activation thresholds. OVA-G4 is widely used in immunology research on altered peptide ligands, T-cell signaling strength, CD8⁺ T-cell functional tuning, immune tolerance, anergy, and antigen-dependent modulation of adaptive immune responses.