Plasmepsin V FRET Substrate

Product Name: Plasmepsin V FRET Substrate

Sequence One Letter Code: Dabcyl-LNKRLLHETQ-EDANS

Sequence Three Letter Code: Dabcyl-Leu-Asn-Lys-Arg-Leu-Leu-His-Glu-Thr-Gln-EDANS

Chemical Formula:C81H120N23O20S1

Molecular Weight: 1751.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: Plasmodium

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Plasmepsin V FRET Substrate is a fluorescence resonance energy transfer peptide designed for measuring Plasmepsin V activity, an endoplasmic reticulum aspartic protease from Plasmodium falciparum. The sequence is derived from the conserved PEXEL motif of histidine-rich protein II, which Plasmepsin V recognizes and cleaves at the RXL site. This processing step is essential for exporting parasite proteins into host erythrocytes. The FRET design enables real-time monitoring of enzymatic activity. This substrate is widely used in malaria research, enzymology studies, protease assay development, and antimalarial drug screening targeting parasite protein export.